Toxicologia: Teratogênese e Desenvolvimento

Ementa:

A disciplina tem como objetivo estudar os mecanismos ligados a ocorrência de teratologia e distúrbios do desenvolvimento. Serão abordados os seguintes tópicos: etiologia das malformações congênitas; toxicologia de medicamentos, praguicidas, plantas e outros agentes tóxicos que afetam o desenvolvimento embrionário; fatores que afetam o desenvolvimento ligados a medicamentos e praguicidas; e fatores que afetam o desenvolvimento ligados a diversos agentes.

Bibliografia:

HAYES, A. W. Principles, and methods of toxicology. 3ª ed. New York: Raven, 1994.
HOOD, R. D. Developmental and reproductive toxicology: a practical approach. 2nd. ed. London: CRC Press, 2006.

SPINOSA, H. S.; GÓRNIAK, S. L.; PALERMO-NETO, J. Toxicologia Aplicada à Medicina Veterinária. 1ª ed. São Paulo, Brasil, Editora Manole, 2008.

SZABO, KT. Congenital Malformations in Laboratory and Farm Animals,1a ed. São Diego, California, Academic Press Inc.,1989.

Bibliografia adicional

1-CHUNG DD, PINSON MR, BHENDERU LS, LAI MS, PATEL RA, MIRANDA RC. Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood. Int J Mol Sci. 2021 Aug 16;22(16):8785. doi: 10.3390/ijms22168785. PMID: 34445488; PMCID: PMC8395909.

2-WACHHOLZ GE, DO AMARAL GOMES J, BOQUETT JA, VIANNA FSL, SCHULER-FACCINI L, FRAGA LR. Molecular mechanisms of Zika virus teratogenesis from animal studies: a systematic review protocol. Syst Rev. 2021 May 29;10(1):160. doi: 10.1186/s13643-021-01713-6. PMID: 34051864; PMCID: PMC8164069.

3-GAO S, WANG S, FAN R, HU J. Recent advances in the molecular mechanism of thalidomide teratogenicity. Biomed Pharmacother. 2020 Jul;127:110114. doi: 10.1016/j.biopha.2020.110114. Epub 2020 Apr 15. PMID: 32304852.

4-ALVES CDS, FRIAS HV, BONAMIN LV, CORREIA MSF, CORRÊA MG, BONDAN EF, DE FÁTIMA M MARTINS M, COELHO CP, BERNARDI MM, SUFFREDINI IB. Luffa operculata at a late period of gestation dysregulates melatonin and cytokines interfering with weight of dams and their male offspring. J Ethnopharmacol. 2021 Jul 15;275:113867. doi: 10.1016/j.jep.2021.113867. Epub 2021 Apr 21. PMID: 33892067.

5-JOAQUIM AO, COELHO CP, MOTTA PD, BONDAN EF, TEODOROV E, MARTINS MFM, KIRSTEN TB, CASARIN RCV, BONAMIN LV, BERNARDI MM. Transgenerational effects of a hypercaloric diet. Reprod Fertil Dev. 2017 Feb;29(2):325-335. doi: 10.1071/RD15165. PMID: 26304066.

6-GERARDIN DC, PEREIRA OC, KEMPINAS WG, FLORIO JC, MOREIRA EG, BERNARDI MM. Sexual behavior, neuroendocrine, and neurochemical aspects in male rats exposed prenatally to stress. Physiol Behav. 2005 Jan 31;84(1):97-104. doi: 10.1016/j.physbeh.2004.10.014. Epub 2004 Nov 14. PMID: 15642612.

7-SANT'ANA MG, SPINOSA HS, FLORIO JC, BERNARDI MM, OLIVEIRA CA, SARKIS JE, KAKAZU MH. Role of early GnRH administration in sexual behavior disorders of rat pups perinatally exposed to lead. Neurotoxicol Teratol. 2001 Mar-Apr;23(2):203-12. doi: 10.1016/s0892-0362(01)00118-0. PMID: 11348839.

8-MENDES-LIMA T, KIRSTEN TB, RODRIGUES PS, SAMPAIO ACS, FELÍCIO LF, ROCHA PRDA, REIS-SILVA TM, BONDAN EF, MARTINS MFM, QUEIROZ-HAZARBASSANOV N, BERNARDI MM. Prenatal LPS induces sickness behaviour and decreases maternal and predatory behaviours after an LPS challenge. Int J Neurosci. 2020 Aug;130(8):804-816. doi: 10.1080/00207454.2019.1706505. Epub 2020 Jan 9. PMID: 31916878.