Tópicos em biologia tumoral

Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental

Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental da UNIP é nota 5 na CAPES
Siga o Programa nas redes sociais:

Topics in tumor biology

Syllabus

Approach of relevant elements in oncology, within a cellular and molecular approach, relating biological characteristics guiding the condition with the elaboration of paths for the diagnosis and therapeutics of these processes. Concept, classification, differences between benign and malignant neoplasms. Central biological characteristics, proliferative circuitry and tumoral metabolism. Diagnostic principles: Cytopathology, Histopathology and immunohistochemistry. Tumor microenvironment and numbness. Metastasis. Therapeutic Strategies.

Bibliography

BOROVSKI, T.; MELO, F.S.; VERMEULEN, L.; MEDEMA, J.P. Cancer stem cell niche: the place to be. Cancer Research, v. 7, p. 634-639, 2011.
EVANS, C. E.; BRANCO-PRICE, C.; JOHNSON, R. S. HIF-mediated endothelial response during cancer progression. International Journal of Hematology, v. 95, n. 5, p. 471-477, 2012.
FOUAD, Y.A.; AANEI, C. Revisiting the hallmarks of cancer. Am J Cancer Res, v.7, p.1016-1036, 2017.
GEISSMANN, F.; MASS, E. A stratified myeloid system, the challenge of understanding macrophage diversity. Semin Immunol. v. 27, n.6, p.353-6, 2015.
HANAHAN, D.; WEINBERG, R.A. The hallmarks of cancer. Cell, v. 100, n. 1, p. 57-70, 2000.
HANAHAN, D.; WEINBERG, R.A. The hallmarks of cancer: the next generation. Cell, v. 144, n. 5, p. 646-674, 2011.
JIE, L.; CHEN, J.L.; QIN, Z. Multifaceted tumor stromal fibroblasts. Cancer Microenvironment, v. 5, n.3, p.187-193, 2012.
MILLS, C.D. M1 and M2 macrophages: oracles of health and disease. Critical Reviews in Immunology, v. 32, n.6, p. 463-488, 2012.
PIETRAS, K.; OSTMAN, A. Hallmarks of cancer: interactions with the tumor stroma. Experimental Cell Research, v. 316, p. 1324-1331, 2010.
RAMOS-VARA, J.A. Technical aspects of immunohistochemistry. Veterinary pathology, v. 42, n. 4, p. 405-426, 2005.
ROSENBLOOM, D.I.S. et al. Evolutionary scalpels for dissecting tumor ecosystems. Biochimica et Biophysica Acta Rev Cancer, v.1867, n.3, p. 69-83, 2017.
RUEGG, C. Leukocytes, inflammation, and angiogenesis in cancer: fatal attractions. Journal of Leukocyte Biology, v. 80, n. 4, p. 682-4, 2006.
SAMPIERI, K.; FODDE, R. Cancer stem cells and metastasis. Seminars in Cancer Biology, v. 22, p. 187-193, 2012.
SCHEEL, C.; ONDER, T.; KAMOUB, A.; WEINBERG, R.A. Adaptation versus selection: the origins of metastatic behavior. Cancer Research, v. 87, p. 11476- 11480, 2007.
SHIBUE, T.; WEINBERG, R.A. Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Seminars in Cancer Biology, v. 21, p. 99-106, 2011.
SLEEMAN, J.P.; CHRISTOFORI, G.; FODDE, R.; COLLARD, J.G.; BERX, G.; DECRAENE, C.; RUEGG, C. Concepts of metastasis in flux: the stromal progression model. Seminars in Cancer Biology, v. 22, p. 174-186, 2012.
TALMADEE, J.E.; DONKOR, M.; SCHOLAR, E. Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Reviews, v. 26, p. 373-400, 2007.
TALMADGE, J.E. Clonal selection of metastasis within the life history of a tumor. Cancer Research, v. 67, p. 11471-11475, 2007.
MEDZHITOV, R. Inflammation 2010: new adventures of an old flame. Cell, v. 140, p. 771-776, 2010.
URABE, F. et al. The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment. Clin Trans. Me d., 6: 45, 2017.
WEINBERG, R.A. A biologia do câncer. Porto Alegre: Artmed, 2008.
YI, S.; HAO, Y.; NAN, K.; FAN, T. Cancer stem cell niche: a target for novel cancer therapeutics. Cancer Treatments Reviews, v. 39, p. 290-296, 2013.