Tópicos em Biologia Tumoral

Ementa

Estudo dos elementos relevantes da biologia tumoral, dentro de um enfoque celular e molecular, destacando-se aspectos relativos às células neoplásicas, ao microambiente tumoral e a resposta do hospedeiro, em associação aos principais métodos de investigação destes eventos. Os temas centrais são: circuitaria molecular no câncer: ciclo celular, proliferação e diferenciação celular; imuno-histoquímica: princípios e aplicações, recuperação antigênica e sistemas de amplificação; genética molecular do câncer: instabilidade cromossômica e mutações, oncogenes, genes supressores de tumores, eventos epigenéticos; estroma e invasão tumoral: vasculogênese tumoral (contexto molecular, padrões de organização, marcadores e quantificação), MEC e câncer, hipóxia e progressão tumoral; inflamação, macrófagos, células dendríticas, células natural-killer e câncer; câncer como doença sistêmica/metástase.

Bibliografia

ANDERSON J.P.; LOEB K.R.; LOEB L.A. Multiple mutations and cancer. PNAS, [S.L.], v. 100, n. 3, p. 776-781, 2003.
ASHTON-PROLLA P. et al. Genética Molecular do Câncer. São Paulo: MSG Produção Editorial, 2002.
BASU B.; CHAKROBORTY D.; SARKAR C. Catecholamines regulate tumor angiogenesis. Cancer Research, Chicago, v. 69, n. 9, p. 3727-3730, 2009.
BERNEMAN Z.N.; VAN BOCKSTAELE D.R.; VERMEULEN K. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Proliferation, Oxford, v. 36, n. 3, p. 131-149, 2003.
CHEN JJW. et al. Tumor-associated macrophages: the double-edged sword in cancer progression. Journal of Clinical Oncology, New York, v. 23, n. 5, p. 953-964, 2005.
COUSSENS L.M.; TLSTY T.D. Tumor stroma and regulation of cancer development. Annual Review of Pathology, San Francisco, v. 1, p. 119-50, 2006.
DE WEVER O.; MAREEL M. Role of tissue stroma in cancer cell invasion. The Journal of Pathology. London, v. 200, n. 4, p. 429-447, 2003.
DIAZ-CANO S.J. General morphological and biological features of neoplasms: integration of molecular findings. Histopathology, Oxford, v. 53, n. 1, p. 1-19, 2008.
ELLIS L.M.; HICKLIN D.J. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Journal of Clinical Oncology, New York, v. 23, n. 5, p. 1011-1027, 2005.
FAVARO, E.; AMADORI, A.; INDRACCOLO, S. From tumor lymphangiogenesis to lymphovascular niche. APMIS, v. 116, p. 648-659, 2008.
FOX S.B.; HARRIS A.L. Histological quantitation of tumour angiogenesis. APMIS, Copenhagem, v. 112, n. 7, p. 413-430, 2004.
FREIREICH E.J.; ESTROV Z.; KURZROCK R. Metastasis – an alternative hypothesis. Cancer, New York, v. 103, n. 8, p. 1537-1539, 2005.
GUARINO M. Epithelial-mesenchymal transition and tumour invasion. The International Journal of Biochemistry & Cell Biology, Exeter, v. 39, n. 12, p. 2153-60, 2007.
GUPTA G.P.; MASSAGUÉ J. Cancer metastasis: building a framework. Cell, Cambridge, v. 127, n. 4, p. 679-695, 2006.
HAN Z. et al. Epithelial-mesenchymal transition in tumor microenvironment. Cell & Bioscience, London, v. 1, p. 1-7, 2011.
HANAHAN D.; WEINBERG R.A. The hallmarks of cancer. Cell, Cambridge, v. 100, n. 1, p. 57-70, 2000.
HANAHAN D.; WEINBERG R.A. The hallmarks of cancer: the next generation. Cell, Cambridge, v. 144, n. 5, p. 646-674, 2011.
JOYCE, J.A.; POLLARD, J.W. Microenvironmental regulation of metastasis. Nature Reviews. Cancer, London, v. 9, n. 4, p. 239-252, 2009.
KLEIN, C.A. Parallel progression of primary tumours and metastasis. Nature Reviews. Cancer, London, v. 9, n. 4, p. 302-312, 2009.
KROEMER G.; POUYSSEGUR, J. Tumor Cell Metabolism: Cancer's Achilles´ Heel. Cancer Cell Review, Cambridge, v. 13, n. 6, p. 472-482, 2008.
LEONG ASY.; LEONG TY. How does antigen retrieval work? Advances in Anatomic Pathology, New York, v. 14, n. 2, p. 129-131, 2007.
LEWIS C.; MURDOCH C. Macrophage responses to hypoxia-implications for tumor progression and anti-cancer therapies. The American Journal of Pathology, v. 167, n. 3, p. 627-35, 2005.
LYDEN, D.; PSAILA, B. The metastatic niche: adapting the foreign soil. Nature Reviews. Cancer, London, v. 9, n. 4, p. 285-293, 2009.
MAQUART F.X.; WEGROWSKI Y. Chondroitin sulfate proteoglycans in tumor progression. Advances in Pharmacology, New York, v. 53, p. 297-321, 2006.
MURPHY M. E. Regulation of cell death in oncogenesis. Cancer Research, [S.L.], v. 65, p. 8069-8071, 2005.
RAMOS-VARA J.A. Technical aspects of immunohistochemistry. Veterinary pathology, [S.L.], v. 42, n. 4, p. 405-426, 2005.
RIBATTI D. et al. The structure of the vascular network of tumors. Cancer Letters, Amsterdam, v. 248, n. 1, p. 18-23, 2007.
RUEGG C. Leukocytes, inflammation, and angiogenesis in cancer: fatal attractions. Journal of Leukocyte Biology, New York, v. 80, n. 4, p. 682-4, 2006.
SCAVELLI C. et al. Lymphatics at the crossroads of angiogenesis and lymphangiogenesis. Journal of anatomy, London, v. 204, n. 6, p. 433-449, 2004.
WEBSTER, J.D. et al. Cellular proliferation in canine cutaneous mast cell tumors: associations with c-KIT and its role in prognostication. Veterinary Pathology, [S.L.], v. 44, n. 3, p. 298-308, 2007.
WEINBERG, R.A. A biologia do câncer. Porto Alegre: Artmed, 2008. p. 864