In the period 2021-2024, UNIP's PPGO published 85 high-impact articles. There has been significant progress in the quality and impact of scientific production. The Field-Weighted Citation Impact (FWCI), a metric that assesses the impact of citations of articles, researchers, research groups or institutions compared to the global average of the area of knowledge, grew from 1.21 in the previous four-year period to 1.33 in the 2021-2024 period. This index indicates that PPGO-UNIP publications received 33% more citations than the global average for the area, showing not only the quantity, but also the relevance and scientific influence of the Program's academic output.
Outstanding Productions by Program Professors (2021-2024)
Caption:
CAPITAL LETTER = Student/returning student
(DO) = Teacher
(PN) = National Partner
(PI) = International Partner
(PD) = Post-Doctorate
(IC) = Scientific Initiation
The Professors are listed below in alphabetical order.
Adriano Fonseca de Lima
1. Lima AF (DO), Calamita RS (IC), Oliveira AA (IC) - Manufacturing process for zirconia primer and final product obtained - Patent filed with the National Institute of Intellectual Property (INPI) - Process number BR 10 2022 022926 0.
This patent application is the result of a Scientific Initiation project carried out by student Rafael Soares Calamita, in collaboration with Amanda André Diniz de Oliveira, both supervised by Prof. Adriano Lima. The project was supported by FAPESP through a Scientific Initiation Grant (IC) and its results were published in the renowned journal “Dental Materials” (impact factor: 4.4; Qualis A1).
The filing of this patent represents a significant milestone, demonstrating not only the scientific relevance of the study, but also its high innovative potential and the possibility of a direct impact on society, should the findings result in the commercialization of a new product.
Specifically, the patent refers to the development of an innovative primer for chemical adhesion to zirconia and metals, obtained through the strategic combination of two functional monomers: the widely used 10-MDP and GPDM. The synergy between these monomers can improve adhesion depending on the surface or material applied, as well as making it possible to reduce the concentration of 10-MDP. This optimization not only improves the system's performance, but can also have a positive impact on the cost of production, making the primer more accessible and viable for clinical and industrial application.
2. SALVADOR MV, Fronza BM (DO), Pecorari VGA (DO), Ogliari FA (PN), Braga RR (PN), Oxman JD (PI), et al. Physicochemical properties of dental resins formulated with amine-free photoinitiation systems. Dent Mater. 2021;37(9):1358-65.
This study was carried out in collaboration with Prof. Roberto Ruggiero Braga, from the University of São Paulo, and Dr. Joe Oxman, who, at the time of the project, was working as a chemist at the 3M company, responsible for developing new products. The research focused on the development and analysis of new dental resin formulations, eliminating the use of tertiary amines, whose potential risks to human health have been widely questioned by regulatory bodies, especially ECHA. Given these concerns, the search for innovative alternatives has become essential to guarantee the safety and efficacy of dental materials. The results of the study demonstrated the viability of new amine-free resin systems, showing excellent polymerization and superior mechanical properties, consolidating a promising alternative for the dental market. This work was the result of the master's thesis of Marcos Vinícius O. Salvador, under the supervision of Prof. Adriano F. Lima, and its impact was recognized with publication in the prestigious journal “Dental Materials” (impact factor: 4.6; Qualis A1), reinforcing the scientific and technological relevance of the research for the advancement of dental restorative materials.
3. Delgado AH, Sauro S, Lima AF (DO), Loguercio AD, Della Bona A, Mazzoni A, et al. RoBDEMAT: A risk of bias tool and guideline to support reporting of pre-clinical dental materials research and assessment of systematic reviews. J Dent. 2022;127:104350.
This article was developed with the aim of establishing new criteria for assessing the risk of bias in systematic reviews of in vitro studies on dental materials. This proposal represents a significant advance, since, until now, risk of bias analyses in in vitro studies were based on criteria originally developed for clinical studies, failing to take into account crucial aspects of laboratory research. This limitation compromised the quality and reliability of systematic reviews in the area. The article had the collaboration of 26 internationally renowned researchers, specialists in different types of dental materials and in vitro study methodologies. These experts actively contributed to defining the topics and structuring the criteria presented, making the work a robust reference for the field.
The participation of Prof. Adriano F. Lima, a permanent lecturer at PPGO-UNIP, reinforces not only the quality and scientific rigor of the research carried out in the UNIP laboratory, but also the international recognition of the institution's teaching staff, consolidating their contribution to the advancement of dental materials science.
4. Lima AF (DO), PIZZANELLI GG, Stolf CS, Salomon JP, Lalevée J (PI), Andia DC (DO). Novel co-initiators of polymerization: Cytotoxicity profile and modulation of inflammatory mediators in human dental pulp stem cells. Dent Mater. 2024;40(10):1692-6.
This study was carried out in collaboration with Prof. Jacques Lalevée, from the Institute of Materials Science in Mulhouse, Université de Haute-Alsace (France), and represents the first work linked to the FAPESP Research Grant - Initial Project, awarded to Prof. Adriano F. Lima, with the participation of a Master's student and professor Denise C. Andia. Andia. The study focused on evaluating the biocompatibility of new polymerization co-initiators developed in Prof. Jacques Lalevée's laboratory, demonstrating that these agents have low toxicity to pulp cells and are a promising alternative to the co-initiators currently used.
This research is even more relevant given the concerns expressed by the ECHA about the toxicity of the tertiary amines used in commercial resin systems, which could lead to future restrictions on their clinical use. Given this scenario, the search for new compounds with lower toxicity has become an essential line of research for the development of safer and more biocompatible dental materials.
The impact of this study was recognized with its publication in the prestigious “Dental Materials” (impact factor: 4.6; Qualis A1), the most influential journal in the field of dental materials in the world. This achievement underscores the excellence and relevance of the research conducted at the PPGO at Universidade Paulista, consolidating its contribution to innovation and safety in restorative dentistry.
Alfredo M. M. Mesquita
1. BELLA APGSN, TUZITA AS, Suffredini IB (DO), Kojima AN (PN), Giovani EM (DO), Mesquita AMM (DO). Bacterial infiltration and detorque at the implant abutment morse taper interface after masticatory simulation. Scientific Reports. 2022;12:17103.
This study is the result of the doctoral thesis of Ana Paula Granja Scarabel Nogueira Bella. To carry out the study, mechanical cycling tests were conducted at the Research Laboratory of UNESP - São José dos Campos, under the supervision of Prof. Alberto N. Kojima. At the same time, an advanced bacterial microleakage technique was used, developed at Universidade Paulista (UNIP) by Prof. Ivana Suffredini, from the Postgraduate Program in Pathology. The research was funded by the private sector (R$37,000 from the company SIN - Sistema de Implantes Nacional). The study was also co-authored by Alessandra Sayuri Tuzita, who was a master's student at the time.
Due to the relevance and novelty of this work - since the literature already presented several studies on the stability of the Morse cone connection, but none associating it with mechanical cycling and bacterial microleakage - it was possible to achieve a significant feat. The study also innovated by using an approach that more accurately simulates external contamination, bringing it closer to clinical reality. As a result, the research was published in a high-impact journal with an impact factor of 3.8.
2. Gehrke SA (PI), Cortellari GC (PI), DE Oliveira Fernandes GV, Scarano A (PI), MARTINS RG, CANÇADO RM, Mesquita AMM (DO). Randomized Clinical Trial Comparing Insertion Torque and Implant Stability of Two Different Implant Macrogeometries in the Initial Periods of Osseointegration. Medicina. 2023;59:168.
The study was carried out in collaboration with renowned international researchers, including Prof. Sergio Gehrke, from the University of Murcia (Spain); Prof. Gustavo de Oliveira Fernandes, from the University of Michigan (United States); and Prof. Antonio Scarano, from the University of Chieti-Pescara (Italy). The research is based on a solid clinical foundation and was largely conducted at the Universidade Paulista (UNIP), which also played the role of the main research center and headquarters responsible for the Research Ethics Committee.
Of high clinical relevance, the study analyzed the brace heights of prosthetic components best suited to maintaining peri-implant structures, contributing directly to the definition of more effective approaches to oral rehabilitation. The study was sponsored by a renowned national implant company, Implacil De Bortoli, and was published in a high impact factor journal.
3. MARTINS RG, CASTRO TSD, Dib LL (DO), Gehrke SA (PI), Mesquita AMM (DO). Influence of Restorative Material on the Distribution of Loads to the Bone in Hybrid Abutment Crowns-In vitro Study. Medicina. 2023;59:1188-12.
This study is the result of a master's thesis by student Rafael Garcia Martins, with the participation of former student Tayna Silva de Castro, then a doctoral student at UNIP's PPG. The research had the collaboration of international professor Sergio Gehrke, from the University of Murcia (Spain), who not only contributed to the preparation of the article, but was also a member of the student's thesis committee, acting as a remote co-supervisor and actively participating in the writing of the study.
The project received funding from the private sector, with support from the company Implacil De Bortoli, in the amount of R$48,000. The entire experimental stage was conducted in the laboratory of the Universidade Paulista (UNIP). This study represents a paradigm shift in implant dentistry, challenging the traditional idea of progressive loading, according to which implants should initially receive resin prostheses to minimize the load transmitted to the supporting bone. This study analyzed crowns made from various materials, including polymethylmethacrylate, double-layer zirconia, monolithic zirconia, PEEK abutment with dissilicate crown, metal-ceramic, hybrid resin and monolithic dissilicate. Due to its relevance, the work was published in a prestigious international journal with an impact factor of 2.4.
4. CANÇADO RM, Sakuno A (PN), Floriani F (PI), Zandinejad A (PI), Saraceni CHC (DO), Giovani EM (DO), Mesquita AMM (DO). Impact of aging on the fracture strength of 3D-printed fixed implant prostheses: a comparative analysis of monolithic and bi-layer with or without fiber-reinforced composite frameworks. J. Prosthodont Implant Esthet Reconstr Dent. 2024;------:1-8.
This study is the result of the master's thesis of Renata Moreira Cançado, a PhD student at the PPGO. It was developed at Universidade Paulista (UNIP), in collaboration with international professors Franciele Floriani and Amir Zandinejad, both from the University of Iowa, USA. The work addresses an innovative topic by investigating milled polymeric infrastructures for prostheses on implants, combined with 3D printed superstructures. 3D printing has been widely studied and, empirically, many clinicians are already using printed superstructures due to advances in three-dimensional design. This study highlighted and discussed the need to establish dimensional parameters for making this type of prosthesis associated with fiber infrastructures, enabling the production of metal-free prostheses. The research was co-supervised by Prof. Cintia Helena Coury Saraceni, from the Dentistry area of the PPGO, and received financial support from the company Implacil De Bortoli. Due to its relevance, the study was published in an international journal with an impact factor of 3.4.
Cintia H. C. Saraceni
1. CHIODE MMM, COLONELLO GP, KABADAYAN F, Silva JS, Suffredini IB (DO); Saraceni CHC (DO). Plant extract incorporated into glass ionomer cement as a photosensitizing agent for antimicrobial photodynamic therapy on Streptococcus mutans. Photodiagnosis and Photodynamic Therapy, v. 1, p. 102788-1, 2022.
The result of Michelle Chiode's master's thesis, this research continues a line of studies developed by Prof. Cintia Saraceni, in partnership with Prof. Ivana Suffredini (Pathology Program - UNIP). The project began with the vast availability of plant extracts from the Amazon (extracted with government authorization), whose antimicrobial properties had not yet been explored. After screening more than 2,000 extracts from the UNIP Herbarium, three stood out for their antimicrobial potential against oral pathogens, generating a scientific publication in 2014. In 2018, a new article identified the most effective extract against bacteria involved in caries. From this finding came the innovative proposal to incorporate it into glass ionomer cement in order to enhance its antimicrobial effect without compromising its properties, culminating in another scientific publication in 2019. However, the greenish coloration of the cement due to the presence of the extract led to a new idea: to use the material as a photosensitizing agent in photodynamic therapy, seeking to further reduce the bacterial load in carious cavities. The results were promising, prompting further studies to identify the extract's active ingredient using bioautography and gas chromatography.
Given the success of the research, the next steps include continuing the tests and filing a patent, highlighting the potential of this innovation for dentistry.
2. COLONELLO GP, Suffredini IB (PN), Andia DC (DO), Lima AF (DO), Saraceni CHC. Evaluating antimicrobial, cytotoxic and immunomodulatory effects of glass ionomer cement modified by chitosan and hydroxyapatite. Dental Materials, v. 40, p. 1305-1311, 2024.
The result of a master's thesis, the research makes an innovative contribution to the development of a new dental material by incorporating antimicrobial agents into glass ionomer cement. The study defined, with scientific rigor, the best concentrations of these agents by means of microbiological, cytotoxicity and immunobiological tests. In addition to the mechanical analyses previously carried out during the master's student's CI, the results make it possible to file a patent for this new dental material. The research had the collaboration of Prof. Ivana Suffredini for the microbiological tests and PPGO professors Denise Andia and Adriano Lima, whose expertise enabled the design and execution of the immunobiological and cytotoxicity tests.
Cristina F. Ortolani
1. Ortolani CLF, Alciati CAS, Arruda CN, Narimatsu DMS, Almeida KR, Silva LA, Souza HMM, Alves CCB, Delgado IF. Saúde bucal: conceitos e orientações para educadores. São Paulo: [Editora não informada]; 2024. ISBN 978-65-85592-04-8.
The need to train teachers to promote oral health arose from research that showed gaps in educators' knowledge on the subject (“Evaluation of the knowledge of teachers and caregivers of schoolchildren about procedures for oral trauma”, carried out by Lucas Della Bianca Abreu, a student in the Institutional Program for Scientific Initiation Scholarships in Secondary Education (PIBIC-EM), and the scientific initiation project “Analysis of the Knowledge of Primary School Teachers about Oral Health”). Based on these studies, an innovative, scientifically-based educational book was developed to support teaching practices and disseminate essential information about oral health in schools. The material covers everything from dental structure and physiology to preventive strategies and oral diseases, training teachers to act as multipliers of this knowledge. By offering pedagogical tools applicable to the school environment, the book contributes to the formation of healthy habits and the prevention of oral diseases among children and adolescents. To enable the practical application of this learning, copies were distributed at the Prof. Pedro Voss State School, where the Health at School project takes place, and at schools served by the Sorria Paraty project. The initiative ensures that the content reaches educators directly, increasing its impact on the community. This book represents an important technical-scientific product, bringing together academic research and educational practice, reinforcing the commitment to social transformation through the promotion of oral health.
2. Alciati CAS, Ortolani CLF. Por que é importante escovar os dentes? Promoção da saúde bucal. São Paulo: [Editora não informada]; [Ano não informado]. ISBN 978-65-85592-02-4.
This book was developed out of the need for accessible teaching material to support the promotion of children's oral health, based on experiences with educational projects already developed by the PPGO in schools. The book makes learning more fun and accessible. In recognition of its relevance, the Paraty-RJ City Council and Culture Department sponsored the book's launch at the Paraty International Literary Festival (FLIP), one of the most prestigious literary events in the country. The book continues to be distributed in the “Smile at School” and “Smile Paraty” projects, increasing its impact. This initiative strengthens the promotion of children's oral health and demonstrates the university's commitment to social transformation, integrating teaching, research and extension.
3. Almeida KR, Ortolani CLF. Desenvolvimento de material educacional para promover o aleitamento natural e a saúde bucal na primeira infância. Cartilha: orientações para o incentivo ao aleitamento materno. [Local de publicação]: [Editora não informada]; [Ano não informado].
Research carried out by IC students under the guidance of Prof. Cristina Ortolani (“Interference of Frenotomy in Breastfeeding” and “Evaluation of the Knowledge of Pregnant and Postpartum Women about Oral Hygiene in Children”) identified that many pregnant women and mothers have doubts about the importance of breastfeeding for oral health. To fill this gap, an educational booklet was developed to raise awareness among pregnant women, mothers and health professionals about the relationship between breastfeeding and oral health, preventing problems such as cavities and malocclusions. The material provides clear information on the benefits of natural breastfeeding for stomatognathic development and the risks of non-nutritive sucking. With content validated by specialists in dentistry and pediatrics, the booklet is distributed in health centers and programs for pregnant women, in printed and digital form, guaranteeing access to well-founded information. A total of 100 printed booklets and 1,000 digital booklets were made available and are still being distributed to mothers who have given birth at the maternity hospital in Franco da Rocha - SP and other municipal maternity hospitals.
This initiative promotes better breastfeeding practices, helps form healthy habits and contributes to the prevention of early oral problems. As well as reinforcing the importance of breastfeeding, the booklet is an essential tool for promoting children's health and well-being, especially in vulnerable populations.
Denise C. Andia
1. Assis RIF (PN), Racca F (PI), FERREIRA RS, Ruiz KGS (PN), da Silva RA (PN), Clokie SJH (PI), Wiench M (PI), Andia DC (DO). Osteogenic commitment of human periodontal ligament cells is predetermined by methylation, chromatin accessibility and expression of key transcription factors. Cells. 2022;11(7):1126. doi:10.3390/cells11071126.
This article marks the beginning of the development of the Bioinformatics area, within the Omics area, at UNIP's PPGO, promoting advances in scientific knowledge and developing this new sub-area, which is so essential in the larger area of Health. The results of this article were obtained with bilateral funding from FAPESP/University of Birmingham, UK (2017/07944-5), demonstrating the results of the internationalization that began in 2015.
This article is Chapter 1 of the Doctoral Thesis defended in 12/2021, when the permanent professor of the Program was still a collaborating researcher at FOP/UNICAMP. The results were presented at SBPqO, in the Hatton modality.
Article accepted for the “Special Issue” of the journal Cells, entitled “Epigenetics in Periodontal Disease Diagnosis, Systemic Interactions and Treatment” (https://www.mdpi.com/journal/cells/special_issues/Epigenetics_Periodontal_Disease).
It represents the consolidation of the permanent professor's line of research within Dentistry and the UNIP Postgraduate Program.
International collaboration with Dr. Wiench - University of Birmingham, UK, which began in 2015 and has already generated three international publications.
Article that brings new methodology to UNIP's PPGO, which is global epigenetic analysis, of the genome as a whole, associated with Bioinformatics analysis, which are, therefore, two areas recently inserted into UNIP's PPGO.
FERREIRA RS, Assis RIF (PN), Racca F (PI), Bontempi AC (IC), da Silva RA (PN), Wiench M (PI), Andia DC (DO). Analyzes in silico indicate the lncRNAs mir31hg and linc00939 as possible epigenetic inhibitors of the osteogenic differentiation in PDLCs. Genes (Basel) 2023;14(8):1649. doi: 10.3390/genes14081649.
2. FERREIRA RS, da Silva RA (PN), Feltran GDS (PN), da Silva EP (PN), de Assis RIF (PN), Rovai ES (PN), Zambuzzi WF (PN), Andia DC (DO). JARID1B represses the osteogenic potential of human periodontal ligament mesenchymal cells. Oral Dis. 2024;30(6):3971-3981. doi:10.1111/odi.14814.
Rogério Salinas Ferreira's doctoral thesis, comprising articles 2 and 3, stood out for its collaboration with IC students (FAPESP scholarship) and national and international partnerships, demonstrating the excellence of the PPGO-UNIP. The articles expanded the subfield of Omics in Health, with Bioinformatics analysis, providing training and autonomy for the PPGO. In line with the project funded by FAPESP, they analyzed epigenetic mechanisms of mineralized tissue regulation, addressing in vitro and in silico investigations.
The articles were published in selective journals, with one being funded by UNIP's publication incentive policy. The results pointed to relevant targets for distinguishing different bone metabolism profiles, contributing to clinical decision-making in dentistry. With a significant impact on bone biology, the research has consolidated the PPGO as a reference in this area, advancing knowledge in the regulation of bone tissue and strengthening UNIP's academic and scientific scene.
3. FERREIRA RS, Assis RIF, Feltran GDS, do Rosário Palma IC, Françoso BG, Zambuzzi WF, Andia DC, da Silva RA. Genome-wide DNA (hydroxy) methylation reveals the individual epigenetic landscape importance on osteogenic phenotype acquisition in periodontal ligament cells. J Periodontol. 2022;93(3):435-448. doi: 10.1002/JPER.21-0218.
The result of a Master's project funded by CAPES and conducted by Rogério Salinas Ferreira, this study culminated in the publication of an article in the renowned Journal of Periodontology (impact factor: 4.2; Qualis A1). Internationally recognized as one of the main references for high-impact research in the field of Periodontics, the journal has become the stage for the dissemination of an unprecedented scientific achievement: the first methylome of human periodontal ligament cells with different capacities for producing mineral nodules. This breakthrough not only highlights the relevance of the project, but also reinforces the importance of the results obtained for the scientific community. The research highlights the excellence of the activities developed by UNIP's PPGO professors, who benefit from strategic collaborations with other postgraduate programs in areas such as cell culture and molecular biology. In addition, the project highlights the incorporation of advanced methodologies, such as OMIC approaches, integrated into the PPGO by Prof. Denise. This innovation highlights the cutting-edge infrastructure and global representativeness of the PPGO-UNIP research group, reaffirming its position as a center of excellence and scientific leadership on the international stage.
Elcio Magdalena Giovani
1. Marques, FCC (DE); Suffredini, IB (DO); GiovanI, ÉM (DO). Diagnosis and Assessment of Oral Health Conditions Among Institutionalized and Non-institutionalized Elderly Individuals. Oral Surgery Oral Medicine Oral Pathology Oral Radiology, v. 136, p. e47, 2023.
This product is the result of research dedicated to improving the oral health of elderly people, promoting not only dental interventions but also a humanized welcome. Initially, patients were given guidance and psychological preparation, creating an essential bond for successful treatment.
The actions carried out have rescued the oral health, self-esteem and self-confidence of these elderly people, many of whom live in a situation of abandonment and rarely receive family visits. The positive impact of this initiative goes beyond dentistry, promoting well-being and dignity for this vulnerable population. In addition to the direct benefits to patients, the research resulted in a guiding document for the care of the oral health of the elderly, serving as a reference for future actions and policies aimed at this public.
2. SILVA AC, Giovani EM (DO). Prevalence of periodontitis in young adults living with HIV/Aids using antiretroviral therapy. RGO. Revista Gaúcha de Odontologia (online), v. 71, p. e20230017-e20230023, 2023. Qualis B1.
Carried out during the Covid-19 pandemic, this research faced significant challenges due to the fear and vulnerability of immunosuppressed patients. Many started the study but dropped out fearing contamination, exacerbating the difficulty of data collection.
The big difference in this study was its target population: young people who had just started sex and had been diagnosed with HIV/Aids. This age group had rarely been researched in dentistry, making the study an innovative reference in the field.
The positive impact of the study expanded knowledge about dental care for this audience, providing essential data for future clinical and scientific approaches.
3. CORASSARI CCS, Pecorari VGA (DO), Giovani EM (DO). Comparison of malachite green and methylene blue dyes in non-surgical periodontal treatment in patients living with HIV/Aids and undergoing immune reconstitution. Foco (Faculdade Novo Milênio), v. 17, p. e6006-13, 2024. Qualis A4.
This innovative research focused on patients undergoing immune reconstitution, many of whom were on the verge of death and facing extreme depression. The aim was to find effective therapeutic approaches without systemic compromise, guaranteeing safe and effective treatment.
The success of this approach resulted in new research exploring alternative therapeutic options, which not only avoided unwanted effects, but also had an extremely positive impact on patients. The study has become a landmark in dentistry, influencing recommended conduct for similar cases.
Fabiano Cirano
1. Cirano FR (DO), ÓBICE ALS, GIRLANDA FF, Monteiro MF (PN), Pimentel SP (DO), Casati MZ (DO), Corrêa MG (DO). May dental implant macro and microgeometry modifications influence peri-implant bone repair in smokers? A randomized clinical trial. BMC Oral Health. 2024 Dec 4;24(1):1475. doi: 10.1186/s12903-024-05188-4. PMID: 39633324; PMCID: PMC11619152.
The work, the result of a doctoral thesis, stands out for its innovative and technological approach, aimed at improving the predictability of rehabilitation procedures in patients at risk. The research investigates biomechanical and molecular mechanisms, driving innovative therapeutic strategies and increasing the safety and efficacy of treatments. The study reflects the PPGO's commitment to generating applied knowledge, directly impacting the population's quality of life. With funding from a private company, the research has achieved scientific recognition, resulting in publication in a high impact factor journal.
2. Cirano FR (DO), MOLEZ AM, Ribeiro FV (DO), Tenenbaum HC (PI), Casati MZ(DO), Corrêa MG (DO), Pimentel SP (DO). Resveratrol and insulin association reduced alveolar bone loss and produced an antioxidant effect in diabetic rats. J Periodontol. 2021 May;92(5):748-759. doi: 10.1002/JPER.19-0718.
This pre-clinical study, the result of an international partnership with the University of Toronto, investigated the effects of the combination of resveratrol and insulin on the control of experimental periodontitis in diabetic rats. The results showed that this combined approach may be more effective in controlling periodontitis in diabetics, paving the way for new therapeutic strategies and strengthening the integration between the management of periodontitis and diabetes mellitus.
The research reinforces the PPGO's mission to generate applied knowledge with a direct impact on health and disease prevention. Its recognition is reflected in its publication in an important periodontics journal, consolidating its scientific relevance.
Fernanda Ribeiro
1. Ribeiro FV (DO), Mehta JJ (PI), Monteiro MF (PN), Moore J (PI), Casati MZ (DO), Nibali L (PI). Minimal invasiveness in nonsurgical periodontal therapy. Periodontol 2000. 2023 Feb;91(1):7-19. doi: 10.1111/prd.12476. Epub 2023 Jan 20. PMID: 36661203.
This review analyzed the effectiveness of periodontal therapies, highlighting that non-surgical approaches can be effective alternatives for periodontal management, especially in less complex cases. The study contributes to a more personalized and less invasive treatment, in line with evidence-based clinical practices.
The work involved the participation of renowned national and international authors, who were invited to publish it in the journal with the highest impact in Periodontics (Qualis A1), an essential reference for clinicians and specialists in the field.
Luciano Lauria Dib
1. Malateaux G, Salazar-Gamarra R, Silva JS, Pecorari VGA, Suffredini IB e Dib LL. Ultraviolet C as a method of disinfecting medical silicone used in facial prostheses: An in vitro study. J Prosthet Dent, 2021, 126(3): 452.E1-452.E6.
This production is the result of a master's thesis, with CAPES funding (88887.488989/2020-00). The production also involved the participation of three professors from UNIP's PPGO, a PhD student from UNIP's Biomedicine Graduate Program, a graduate of UNIP's PPGO and a partnership with the private company O2 LED.
This was the first work in a line of research involving disinfection with ultraviolet C light and oral and maxillofacial prostheses, bringing unprecedented and promising scientific results regarding the use of UV-C light for this purpose. This study led to the development of a pioneering product called Sterface, developed in partnership with the company O2 Led, with the aim of sterilizing facial prostheses. The process of submitting a patent for the product has begun and the application is still pending. With this equipment, the maintenance of facial prostheses will be improved, reducing the risk of skin and implant contamination, and the durability of prostheses will increase, with greater benefits for patients and a reduction in costs, generating great social impact, avoiding frequent prosthesis changes and not overloading the health system.
2. Schnorr NGP, Salazar-Gamarra R, Latuff DC, Dib LL. Oculofacial Prosthetic Rehabilitation Complemented With Temporary Fillers and Neurotoxin. J Craniofac Surg. 2022 Jul-Aug 01;33(5):e482-e488.
This production is the result of a master's thesis, funded by CAPES, carried out in partnership with the Mais Identidade Institute and the private company Renova. In addition to the master's student, a graduate student (SGR) and a doctoral student (LDC) took part, as well as the lecturer (DLL). The study was a pioneer in using dermopreenchers to correct facial defects, making it possible to make smaller, more aesthetic facial prostheses. With this development, patients were able to have results that generated greater comfort in the use of prostheses and greater self-confidence, generating a great impact on quality of life. The use of dermoprene fillers for this purpose, combined with digital technology for the production of prostheses, has led to a change in the process of planning and executing prostheses, becoming a reference in several centers that make facial prostheses, reducing the cost and time of production, and providing more aesthetic and functional results.
3. Jauregui Ulloa J, Salazar-Gamarra R, Mesquita AMM, Aguirre F, Dib LL. A Digital Method to Fabricate the Ocular Portion of An Orbital Prosthesis with A Smartphone Camera, Color Calibration and Digital Printing Prosthodont. 2021 Jan;30(1):91-94.
This production is the result of a master's thesis funded by CAPES, carried out in partnership with the Mais Identidad Institute and the OREMA Foundation - Chile. The study involved a master's student (JUJ), an alumnus (SGR), two professors from the program (MMA and DLL) and an international partner (AF). The absolutely innovative methodology changed the way the ocular portion of the oculopalpebral prosthesis is produced, using photos of the patients themselves. The method reduces the time and cost of manufacturing the eyepieces, obtaining more predictable results that are compatible with each patient. The product of this research is being used in the routine manufacture of prostheses at the Mais Identidade Institute, impacting on patients' quality of life and promoting social reintegration with lower production costs.
4. Navarro Jr H, Dib LL, Salazar-Gamara R, Mesquita AMM, De Bortoli JPA, Nannmark U. Craniofacial implant intrusion risk: an in vitro study on the role of macrostructure in type I and IV bones - Submetido ao International Journal of Dentistry sob o ID 7688631.
The production is the result of a doctoral thesis carried out with the support of CAPES that investigated the risk of intrusion of craniofacial implants, being an in vitro study on the role of implant macrostructure in type I and IV bones. The research involved a doctoral student, two professors from UNIP's Graduate Program, an international partner from the University of Gothenburg, and was developed in partnership with the Mais Identidade Institute and with the support of national private industry. The research sought to evaluate the efficacy and risk of implants produced by the national industry for craniofacial use, generating as a product new implants for use in the rehabilitation of severe facial defects. The product obtained was of high impact, with new resources to promote the aesthetic and functional rehabilitation of patients severely affected by deformities.
This material produced by the national industry is more accessible both economically and from a logistical point of view, enabling the rehabilitation and social reintegration of patients affected by severe deformities and who live away from social and working life. With the use of national implants, rehabilitation is more economical and can be carried out more quickly and efficiently, promoting family and work reintegration.
Marcio Zaffalon Casati
1. NOMIYAMA LM, MATUMOTO EK, Corrêa MG (DO), Cirano FR (DO), Ribeiro FV (DO), Pimentel SP (DO), Casati MZ (DO). Comparison between flapless-guided and conventional surgery for implant placement: a 12-month randomized clinical trial. Clin Oral Investig. 2023 Apr;27(4):1665-1679. doi: 10.1007/s00784-022-04793-3. Epub 2022 Nov 19. Erratum in: Clin Oral Investig. 2023 Jun;27(6):3285. doi: 10.1007/s00784-023-05045-8. PMID: 36401742.
This research, funded by FAPESP and the result of a doctoral thesis, stands out for its innovative and technological character, guiding the choice of more effective and predictable clinical approaches. The findings provide valuable insights into the advantages and limitations of computer-guided techniques, highlighting the importance of balancing surgical precision and the biological processes of osseointegration. The results contribute to the improvement of clinical approaches to oral rehabilitation, providing more comfort and well-being for patients. In recognition of the study's relevance and quality, it has been accepted for publication in a Qualis A1 journal.
2. MUSSI MC, Ribeiro FV (DO), Corrêa MG (DO), Salmon CR (PN), Pimentel SP (DO), Cirano FR (DO), Casati MZ (DO). Impact of a modified implant macrogeometry on biomechanical parameters and bone-related markers in rats. Braz Oral Res. 2023 Apr 28;37:e44. doi: 10.1590/1807-3107bor-2023.vol37.0044. PMID: 37132731.
The research, the result of a master's thesis, was supported by a private company and is innovative in that it explores the development of modifications to dental materials, which could result in better clinical performance of implant rehabilitation approaches. This study not only contributed new scientific evidence, but also generated an important impact by enabling this innovation to be included in the sales catalog of a well-established implant company in the country, expanding its therapeutic options and reinforcing its leadership in the market. It also resulted in publication in a QUALIS A2 journal.
3.MATUMOTO EK, Corrêa MG (DO), Couso-Queiruga E (PI), Monteiro MF (PN), Graham Z (PI), BRAZ SHG, Ribeiro FV (DO), Pimentel SP (DO), Cirano FR (DO), Casati MZ (DO). Influence of partially exposed nonabsorbable membrane for alveolar ridge preservation: A randomized controlled trial. Clin Implant Dent Relat Res. 2023 Jun;25(3):447-457. doi: 10.1111/cid.13202. Epub 2023 Mar 22. PMID: 36946359.
This research, the result of a doctoral thesis, has contributed to the advancement of knowledge, allowing clinical approaches for the rehabilitation of patients with tooth loss to be guided in such a way as to optimize the rehabilitation process. The use of this approach can therefore be considered an effective strategy for preserving the alveolar ridge in specific cases, expanding the therapeutic possibilities in the field of guided bone regeneration. Thus, providing a better quality of life and a more significant social impact. The study received regular support from FAPESP and established international collaborations with professors from renowned universities. As a result, the thesis culminated in the publication of an article in a Qualis A1 journal.
Monica Grazielli Corrêa
1. SANT’ANNA HR, Casati MZ (DO), MUSSI MC, Cirano FR (DO), Pimentel SP (DO), Ribeiro (DO), Corrêa MG (DO). Peri-Implant Repair Using a Modified Implant Macrogeometry in Diabetic Rats: Biomechanical and Molecular Analyses of Bone-Related Markers. Materials (Basel). 2022 Mar 21;15(6):2317. doi: 10.3390/ma15062317. PMID: 35329768; PMCID: PMC8953263.
This research, the result of a master's thesis, is innovative in that it evaluates, for the first time, the impact of implants with modified macrogeometry and a healing chamber on peri-implant repair in diabetic conditions. The findings of this study represent a significant advance in the field of implant dentistry and aid clinical decision-making by introducing an innovative approach to dental implant rehabilitation in diabetic patients.
Highlighting the potential of optimized macrodesign strategies, the research opens up new perspectives for the treatment of these patients, offering a promising solution to overcome the common limitations in implant placement in individuals with diabetes. This results in a positive impact on society, promoting a better quality of life.
The study was carried out with the support of a private company and resulted in a publication in a QUALIS A1 journal.
2. Corrêa MG (DO), Ribeiro FV (DO), Pimentel SP (DO), Benatti BB (PD), Felix Silva PH (PN), Casati (DO), Cirano FR (DO). Impact of resveratrol in the reduction of the harmful effect of diabetes on peri-implant bone repair: bone-related gene expression, counter-torque and micro-CT analysis in rats. Acta Odontol Scand. 2021 Apr;79(3):174-181. doi: 10.1080/00016357.2020.1797159. Epub 2020 Jul 22. PMID: 32697922.
The research, which received support from FAPESP, included the participation of post-doctoral researcher Bruno Benatti, a professor at UFMA, as well as a partnership with USP - Ribeirão Preto and the collaboration of a student from the institution.
The findings of this study have a significant impact on scientific literature, highlighting resveratrol as a possible adjuvant strategy in the treatment of complications related to dental implants in diabetic rats. The results indicate an improvement in recovery and a reduction in complications, providing valuable direction for future clinical research and contributing to the advancement of knowledge in the scientific community. The study was published in a Qualis A1 journal.
Suzana P. Pimentel
1.BRAZ SHG, Monteiro MF (PN), MATUMOTO EK, Corrêa MG (DO), Casarin RCV (PN), Ribeiro FV (DO), Cirano FR (DO), Casati MZ (DO), Pimentel SP (DO). Microbial colonization in the partially exposed nonabsorbable membrane during alveolar ridge preservation. Clin Oral Investig. 2024 Jun 14;28(7):373. doi: 10.1007/s00784-024-05763-7. PMID: 38874776.
This randomized, prospective, controlled clinical trial was part of a master's thesis and explored a frequent clinical situation, investigating highly complex approaches, which demonstrates the feasibility of using dPTFE membranes in controlled exposure, contributing to bone regeneration. These results show information of great clinical relevance that will directly impact rehabilitative approaches and, consequently, increase the chance of success of such procedures and the patient's quality of life. The study was supported by FAPESP and resulted in publication in a journal with a high scientific impact, Qualis A1.
2. VITALE M, Corrêa MG (DO), Ervolino E (PN), Cirano FR (DO), Ribeiro FV (DO), Monteiro MF (PN), Casati MZ (DO), Pimentel SP (DO). Resveratrol for preventing medication-related osteonecrosis of the jaws in rats. Oral Dis. 2024 Apr;30(3):1462-1474. doi: 10.1111/odi.14544. Epub 2023 Mar 13. PMID: 36807967.
This study, the result of a doctoral thesis, explored a clinical situation that has a major negative impact on the patient's quality of life (drug-induced osteonecrosis), as it generates a great deal of pain and discomfort, as well as being difficult to manage and control. We therefore investigated a natural preventative/treatment alternative to the use of anti-resorptive drugs often used for osteoporosis. The research resulted in relevant information from a clinical and molecular point of view, which will help in the treatment of this patient profile and may lead to a better quality of life and less discomfort. This research was also supported by FAPESP, a partnership with other important national institutions (UNESP - Araçatuba) and external professors, resulting in a publication in a journal with a high scientific impact and QUALIS A1.
3. ZAMAI RS, Corrêa MG (DO), Ribeiro FV (DO), Cirano FR (DO), Casati MZ (DO), Messora MR (PN), Pimentel SP (DO). Does resveratrol favor peri-implant bone repair in rats with ovariectomy-induced osteoporosis? Gene expression, counter-torque and micro-CT analysis. Braz Oral Res. 2023 Jan 20;37:e003. doi: 10.1590/1807-3107bor-2023.vol37.0003. PMID: 36700588.
This study, the result of a master's dissertation, is innovative in that it provides unprecedented information on the influence of nutraceuticals on peri-implant bone repair in an important systemic situation, which may direct future research in the search for alternative treatments for this condition. In addition, the research was carried out with regular support from FAPESP and had the partnership of a national university (USP-Ribeirão Preto) of great importance and the participation of professors from the same university, resulting in publication in a Qualis A2 journal.
4. Wagner TP, PIRES PR, Rios FS, de Oliveira JAP, Costa RDSA, Cunha KF, Silveira HLD, Pimentel S (DO), Casati MZ (DO), Rosing CK, Haas AN. Surgical and non-surgical debridement for the treatment of peri-implantitis: a two-center 12-month randomized trial. Clin Oral Investig. 2021 Oct;25(10):5723-5733.
Este artigo resulta de um estudo multicêntrico realizado em parceria entre universidades nacionais, UNIP e UFRGS, envolvendo docentes e discentes de ambas as instituições. Os achados destacam impactos significativos na educação e formação profissional, evidenciando a importância de decisões fundamentadas em evidências científicas. Além disso, os resultados podem ser utilizados por órgãos reguladores e sociedades odontológicas para revisar protocolos e otimizar diretrizes clínicas. Em síntese, o estudo reforça a complexidade do tratamento da peri-implantite e a necessidade contínua de aperfeiçoamento nas estratégias terapêuticas disponíveis.