Apresentação

The Program

Aimed at training qualified researchers and professionals, the Postgraduate Program in Dentistry works in the area of Clinical Dentistry, with a focus on applied scientific research and advanced clinical practice. With lines of research that cover everything from the biological mechanisms of oral diseases to innovative preventive and therapeutic methods, the program promotes solid, interdisciplinary training in line with contemporary oral health challenges.

Target audience

Graduates and post-graduates in dentistry with an interest in scientific research, teaching or professional development in the field of dentistry.

The specific objectives of the Program for each level of training are:

• Master's: to train teacher-researchers so that they acquire a solid foundation and mastery of scientific processes, making them capable of working in national and international teaching institutions, as well as qualifying dental professionals and developing strategies to improve the quality of life of the community.
• Doctorate: to train researchers so that they develop critical thinking skills and scientific maturity, demonstrate sensitivity to social demands, and are prepared to provide guidance, structure lines of research and develop innovative and consistent projects that boost the advancement of knowledge and the quality of life of the population.

The Stricto Sensu Postgraduate Program in Dentistry at Universidade Paulista (PPGO) began its activities in 1992, offering an academic master's degree, and was accredited by CAPES on 30/07/1998. Since then, it has graduated 324 masters and 50 doctors, consolidating its position as a center of excellence in the training of highly qualified teachers and researchers.

Since its creation, the PPGO has fulfilled its mission of training highly qualified teacher-researchers who are able to meet society's demands. In accordance with the PPGO's objectives, graduates of the Program work as civil servants in public bodies, scientific consultants in industry, coordinators of further education and/or lato sensu postgraduate courses in trade associations or private universities, and/or as lecturers at the Institution itself or at other universities.

Between 1998 and 2009, the program remained stable with a CAPES concept of 3. However, based on an institutional analysis of the need for growth and adaptation of the PPGO's objectives, a restructuring process began under the coordination of Prof. Cintia Saraceni. The goals established focused on improving the coherence, consistency and scope of the areas of concentration, lines of research and projects, as well as student training in line with the program's objectives.

One of the first significant changes was the unification of the areas of concentration into a single one: Clinical Dentistry. This new direction allowed for stricter criteria for accrediting and disaccrediting professors, ensuring greater adherence to the profile established for the growth of the PPGO.

The renewal of the teaching staff was essential in this process, starting with the incorporation in the area of Periodontics and Dentistry. In 2010, professors with mastery and expertise in clinical and basic research in periodontics/implants and molecular biology were added. In 2012, a lecturer was added to strengthen and support the Biostatistics area.

The readjustment of research lines and projects, together with a new curriculum, provided more support for student training and allowed for greater coherence between teaching and research. At the same time, a significant institutional investment of more than R$3 million made it possible to build a modern research laboratory in Dentistry, adding to the infrastructure of multidisciplinary laboratories and clinics that are constantly being updated.

These changes have had a direct impact on the growth of the PPGO, as evidenced by the increase in the number of students and the progress made in evaluation indicators such as student training, intellectual production and social inclusion. These results culminated in CAPES concept four being awarded in the 2010-2012 triennial evaluation.

For the 2013-2016 four-year period, strategic planning aimed to expand academic training, promote internationalization and consolidate the PPGO's scientific and technological impact. In 2014, four new professors were hired in the areas of Biomaterials, Molecular Biology and Periodontics, two of them in the Young Permanent Professor category. This growth resulted in the approval of the academic doctorate in 2015, a significant milestone in the Program's trajectory.

The strategic planning for 2017-2020 consolidated the growth of the PPGO, strengthening its multidimensional mission. The lines of research were updated once again to adapt to the dynamic process of knowledge production. The projects were redistributed and linked to the lines, as well as the dissertations/theses and intellectual production, all in coherence with the area of concentration. The curriculum has been revised, adjusted and updated, with an emphasis on teacher-researcher training at both levels, in order to provide training that is compatible with the new ways of offering content and good research practices. The teaching staff was continuously monitored using accreditation criteria that ensured academic excellence and social impact.

The Program's intellectual output has grown exponentially, reflected in student participation, which has risen from 21% to 81%. The socio-economic impact of the PPGO has also been recognized nationally and internationally, driven by partnerships with public services and the third sector.

The Program's internationalization was strengthened with international cooperation projects, academic mobility and high-impact publications. The presence of foreign students is also noteworthy, with four Peruvian students joining the program during the four-year period.

With the implementation of the multidimensional evaluation, the new dimensions were widely reflected on and discussed by the Collegiate and guided decision-making and future actions.
In this process, the new methodologies implemented for the self-assessment process and for monitoring graduates have already provided input for strategic planning for the 2017-2020 quadrennium.

Another aspect to highlight was the alignment and institutional support for the proposals of the postgraduate programs, which offered the support and infrastructure needed to carry out the research, as well as encouraging the participation of students and teachers in scientific events as a way of disseminating the products generated.

The year 2020 was especially challenging in all respects, due to the difficult pandemic situation that imposed significant government budget restrictions, which had a significant impact on all institutions. In order not to jeopardize student training, all the necessary adjustments were made to maintain the teaching-learning process and research.

Despite all the difficulties and challenges, UNIP's PPGO has made progress towards consolidation and has fulfilled its mission: to produce and share knowledge based on scientific evidence, to train qualified human resources who are sensitive to the demands of society, and to contribute to the quality of life, information and care of the population based on the results of its research. The targets set for the 2017-2020 four-year period were met and, based on the identification of weaknesses and potential, new targets and processes for growth were outlined.

The success of the planned actions resulted in the CAPES 5 concept, according to the 2017-2020 quadrennial evaluation. The commission's report highlighted the well-designed structure of the program, the commitment of the teaching staff and the relevance of the scientific production, consolidating the PPGO as a benchmark in the area.

The PPG's objectives were clearly identified by the area committee: “The Program stands out as a trainer of human resources aimed at training for teaching, research management and working with different public sectors that work in the development and implementation of public oral health policy guidelines”.
Finally, there was “institutional commitment to actions aimed at internationalization, especially strengthening actions that expand and intensify bilateral mobility”.

The 2021-2024 quadrennium brought new challenges, mainly due to the impacts of the pandemic. However, the PPGO has maintained its growth trajectory, ensuring the quality of student training, attracting significant external resources and strengthening internationalization. Student participation in high-impact academic production has increased significantly, demonstrating the efficiency of the strategies implemented.

In compliance with the strategic planning established for the 2021-2024 quadrennium, the PPGO aimed to achieve excellence in training (supported by the profile of graduates sought at both levels); in high-level research, the results of which can have an impact on the scientific community; in scientific and technological progress, which allows for the advancement of scientific knowledge and the strengthening of social inclusion actions.

In terms of “Program”, the PPG showed coherence between the area of concentration, lines, research projects and curriculum. The subjects, which are constantly being evaluated, have been readjusted and new ones offered in order to provide a solid, qualified and up-to-date student education, in line with the PPGO's objectives. The results of the CPA proved the success of this aspect, pointing out that 78.8% of students considered that the subjects were up-to-date and contributed to their learning and professional training, fully meeting the objectives and graduate profile proposed by the Program.

The teaching staff underwent changes due to the personal/professional choices of some professors; however, the coordination and the institution worked hard to ensure that the replacements were made as quickly as possible, so as not to have a negative impact on student training and the PPGO's intellectual production. The new hires were made in compliance with the established accreditation criteria, and the new professors have brought new research fronts to the PPG and possibilities for increasing the various modalities that make up internationalization. The teaching staff proved capable of raising funds to carry out research from government agencies and national and international companies. The funding was significant, despite the national and international economic difficulties: Public agencies: R$1,432,757.58/US$119,069.08; National Companies: R$444,400; International Companies: R$313,000.

The self-assessment and graduates committees were restructured and the procedures for gathering information were improved in order to obtain a correct diagnosis of the Program's strengths and weaknesses, for more precise and objective preparation of the strategic planning for the four-year period 2025-2028, in accordance with the guidelines presented by the Dentistry committee. After the collegiate body reflected on the program's objectives based on the results of the self-evaluation process and the monitoring of graduates, it was concluded that they are consistent with the mission and profile of the graduates sought by the PPGO.

In terms of “Training”, there was constant concern about the quality of the theses and the consequent generation of qualified production with a scientific-technological and/or social impact, always with the participation of students. The goal of growth in this area, using the tools and strategies already established for this purpose in the previous four-year period, was maintained and the results were significant. Following the progress achieved in the last four-year period, there was a significant increase in student participation in qualified production (A1: 60%; A2: 55%; A3: 60%; A4: 50%), which proves the success of the measures established for the qualification of theses and dissertations.

A new committee for monitoring graduates was set up and the processes for monitoring graduates were improved in order to detect the impact of the training offered by the PPGO on the fate of graduates and their integration into the job market. The results of this monitoring have shown that PPGO graduates have excelled in various academic and professional spheres, demonstrating the quality and relevance of the training received and the consistency with the training profile established by the PPGO.

The impact on society continues to be one of the Program's strengths. Partnerships with government and third sector institutions have been maintained and new ones signed in order to continue the PPGO's work in training professionals in the public and private sectors, generating research aimed at socially vulnerable populations, disseminating knowledge and, above all, improving the quality of life of the population at local, regional and national level.

The Program's internationalization continued to grow and consolidate, reflected in the international partnerships maintained and new cooperation agreements signed, which generated qualified production with international visibility and contributed to the advancement and dissemination of science. There has been faculty and student mobility, doctoral-sandwich programs, technical visits, participation of international researchers on boards and obtaining international funding.

For the next four years (2025-2028), the PPGO will remain committed to academic excellence, scientific and technological progress and expanding its social impact. With a well-structured strategic plan, the Program will continue on its path of growth and innovation, reaffirming its role as a benchmark in the training of teachers and researchers in Dentistry.

Mission

To train highly qualified teacher-researchers through teaching, research and extension, capable of meeting the demands of society.

Vision

To be a national and international benchmark in the training of teachers and researchers committed to academic excellence, impactful scientific production and social transformation. We aim to contribute to the advancement of knowledge through innovative, ethical and sustainable practices, promoting the integration of teaching, research and extension for the benefit of society.

Values

Ethics, innovation, sustainability, environmental responsibility, national and international cooperation, transparency and solidarity.

Area: Dentistry.

Areas of Knowledge: Biomaterials, Dentistry, Implantology, Laser, Orthodontics, Patients with special needs, Periodontics, Prosthodontics, Collective Health.

Area of Concentration: Clinical Dentistry.

Line 1 Research Projects - Studies of the mechanisms related to the occurrence of stomatognathic system conditions

Research Project: ASSESSMENT OF THE ASSOCIATION BETWEEN PERIODONTAL DISEASE, PERI-IMPLANT AND ENVIRONMENTAL AND SYSTEMIC RISK INDICATORS
Head Teacher: Mônica Grazieli Corrêa

Research Project: STUDY OF CLINICAL AND MOLECULAR FACTORS THAT INFLUENCE BONE INTEGRATION AND MAINTENANCE OF IMPLANT-SUPPORTED REHABILITATIONS
Responsible Teacher: Raissa Micaella Marcello Machado

Research Project: STUDY OF BIOLOGICAL MARKERS, GENE EXPRESSION AND BEHAVIORAL FACTORS RELATED TO THE CONCEPTION OF INJURIES THAT ACOME THE DENTAL ELEMENTS
Professor Responsible: Cintia Helena Coury Saraceni

Research Project: EPIGENETIC REGULATION IN HUMAN MESENE CELLS IN OSTEOGENIC DIFFERENTIATION
Head Teacher: Denise Carleto Andia

Line 2 Research Projects - Prevention, therapy and materials related to stomatognathic system conditions

Research Project: ANALYSIS OF THE SALIVA OF STUDENTS FROM THE TECHNOLOGICAL INSTITUTE OF AERONAUTICS - ITA WITH BURNOUT SYNDROME BY FOURIER TRANSFORM INFRARED SPECTROSCOPY (FT-IR)
Professor responsible: Elcio Magdalena Giovani

Research Project: ANALYSIS OF THE MISCELLANEOUS PERIODONTAL AND PERI-IMPLANT TREATMENT MODALITIES
Responsible Teacher: Fabiano Ribeiro Cirano

Research Project: DATA ANALYSIS IN THE AREA OF COLLECTIVE HEALTH IN ODONTOLOGY
Teacher responsible: Vanessa Gallego Arias Pecorari

Research Project: EVALUATION OF TECHNIQUES AND MATERIALS USED IN REHABILITATION PROCEDURES THROUGH BONE-INTEGRATED IMPLANTS
Professor Responsible: Alfredo Mikail Melo Mesquita

Research Project: BIOLOGICAL CHARACTERIZATION OF EXPERIMENTAL RESIN SYSTEMS CONTAINING DIFFERENT INITIATION SYSTEMS
Professor Responsible: Adriano Fonseca de Lima

Research Project: DETECTION OF NORMALITY ALTERATIONS IN THE MORAL CAVITY OF PATIENTS WITH SPECIAL NEEDS AND IMPLEMENTATION OF THERAPEUTIC CONDUCTS
Head Teacher: Elcio Magdalena Giovani

Research Project: DIAGNOSIS, TREATMENT AND REHABILITATION OF DISEASES AFFECTING THE BUCOMAXILOFACIAL REGION
Head Teacher: Luciano Lauria Dib

Research Project: EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT OF CRANIOFACIAL AND OCLUSAL CHANGES
Professor Responsible: Cristina Lúcia Feijó Ortolani

Research Project: STUDY OF NEW THERAPEUTIC APPROACHES RELATED TO BONE REPAIR
Responsible Teacher: Márcio Zaffalon Casati

Research Project: STUDY OF THE BEHAVIOR OF ODONTOLOGICAL CERAMICS
Responsible Teacher: Alfredo Mikail Melo Mesquita

Research Project: STUDY OF BIOLOGICAL MARKERS RELATED TO THE MODULATION OF PERIODONTAL AND PERI-IMPLANT DISEASE
Professor Responsible: Suzana Peres Pimentel

Research Project: INFLUENCE OF THE INITIATION SYSTEM AND LOW CONTRACTION MONOMERS ON THE BIOMECHANICAL PROPERTIES OF RESIN AGENTS
Teacher responsible: Adriano Fonseca de Lima

The Program has institutional infrastructure to conduct research, without external dependency. In addition to this structure, there is support from services such as:

1. Rooms for theoretical classes and seminars: air-conditioned, equipped with microcomputers, multimedia projectors, DVDs, screens, tables and chairs.
2. Rooms for qualifications and defenses: two air-conditioned rooms, with multimedia projectors, microcomputers, screens, upholstered chairs and a five-seater table for the examining board.
3. Student lounge and teacher lounge: both air-conditioned, equipped with tables, chairs, microcomputers connected to high-speed internet (including wireless network), scanner and printer.
4. Auditoriums: located in the Postgraduate building, they have capacities for 50, 150 and 600 seats, with complete infrastructure for courses and events.
5. Postgraduate Office: provides support to students and professors on the program.
6. Research Ethics Committees : Ethics Committee on the Use of Animals in Research (CEUA) and the Research Ethics Committee (CEP) are active and certified by the National Council for the Control of Animal Experimentation (CONCEA) and the National Council for Research Ethics (CONEP). They meet the demands of teachers and students regarding their projects involving human beings and/or animals.
7. Library: The Indianópolis Library has specialized staff, accessible infrastructure, and areas for individual and group study. It has computers with internet access for research in national and international databases, as well as a diverse collection of books, periodicals, and multimedia . All UNIP libraries are interconnected online, allowing broad access to services and resources 24 hours a day. UNIP continually invests in expanding its collection, which currently has 1,720,314 items. In addition, the university provides access to online databases through the CAPES Portal and is part of the Federated Academic Community ( CAFe ), guaranteeing access to databases such as Web of Science, Scopus , Emerald , and Taylor and Francis.

In all these sectors, the Program has qualified employees trained for their specific functions.

Laboratories and clinics

The laboratory infrastructure is constantly improved based on the needs of researchers, through institutional support and assistance obtained from funding agencies, industries and the third sector.
Since 2010, when the Program was restructured, the University has invested more than R$3 million in an updated research center and clinic that are adapted to the needs of research carried out in various clinical and laboratory areas. This infrastructure was added to the existing research laboratories at UNIP, which are shared with the Graduate Program in Environmental and Experimental Pathology.
In order to improve the infrastructure for laboratories, in 2020 the University invested in the construction of a new research center, measuring 962.56 m2 , which was inaugurated in 2021. Below, we present the infrastructure made available to the Program.

1. Outpatient Care Center and Digital Technology Laboratory (3D) : built next to the dental clinic building in 2019, after the formal establishment of a partnership with Instituto Mais Identidade (+ID), an NGO (OSCIP) dedicated to serving patients with maxillofacial deformities resulting from cancer treatment or traumatic sequelae. The partnership established that the construction of the physical space would be carried out by UNIP and that Instituto +ID would bring equipment acquired through donations from private companies (Rede IMPAR and Banco Itaú). The complex has been in operation since October 2020 and has a scanner intraoral and benchtop machines, three 3D printers, complete equipment for a conventional prosthetic laboratory (microwave ovens, refrigerators, implant motors, electric motors, instruments and materials for prosthetics, among others), as well as complete dentistry equipment, such as dental chairs and equipment . The Institute also has a special room, called a “color room ”. This room has a lighting system that is unprecedented in Brazil, which allows the capture of patients’ skin color with minimal distortion, providing aesthetic results that are far superior to conventional standards. The space is used by professors and students who work in the care and rehabilitation of the population affected by head and neck cancer, as well as patients who need prosthetic rehabilitation, linked to the research projects developed by the Program. This partnership subsidized important products, mentioned below, which strengthen the social impact of the Program.

2. Dental Research Laboratory : the laboratory has equipment purchased by the Institution, as well as through assistance obtained from funding agencies. This equipment allows for the execution of research projects in the various subareas of knowledge that make up the area of concentration in Clinical Dentistry, in addition to analyses in molecular biology, which support clinical and animal research. The equipment is listed below:
1. JEOL scanning electron microscope JSM-6510; 2. JEOL Desk V Metallizer ; 3. JEOL Desk Yarn Carbon Vaporizer (R$ 287,419.24 – UNIP 2011 grant); 4. Future-Tech FM-700 Microhardness Tester (R$ 140,000 – FAPESP 2010); 5. KRATOS KE 2.000MP Universal Testing Machine (R$ 38,400 – UNIP 2011); 6. Luminex MAGPIX Millipore (R$ 112,500 – FAPESP 2011); 7. Buehler IsoMet 1000 Cutter (R$ 24,508 – UNIP 2010); 8. Fume Hood (R$ 1,900 – UNIP 2010 grant); 9. Thermoplate Reader Tp-reader (R$ 19,500 – FAPESP 2011); 10. Extensometer (R$ 35,000 – FAPESP 2012); 11. Gehaka AG200 analytical balance; 12. Centribio 80-2B centrifuge; 13. Labtech water bath for 60 tubes; 14. Permution fume hood ; 15. Gehaka BK3000 electronic balance ; 16. Biomixer 78HW-1 magnetic stirrer ; 17. Vortex stirrer Biomixer QL-901; 18. Ultrasonic bath; 19. Maxipress sample filler Solotest ; 20. Maxicut electric cutter Solotest ; 21. Polisher Maximille Solotest ; 22. Fanem drying and bacteriological ovens (81 and 150 L); 23. Digital caliper; 24. Deionizer ; 25. Peaggmeter ; 26. Semi-automatic pipettors ; 27. ELISA reader; 28. Roughness meter Surtonic 25; 29. Intra-Spin Centrifuge INTRA-LOCK (R$ 4,427.02 – FAPESP 2019); 30. Minicentrifuge K14-060 Kasvi (R$ 1,099 – FAPESP 2016/12758-3); 31. Water bath 201010 Thoth Equipamentos (R$ 1,500 – Asset 01192230); 32. Nanodrop lite – Spectrophotometer – Thermo Fisher Scientific (R$ 17 thousand – FAPESP 2013); 33. Minicentrifuge MCA (R$ 1,100 – FAPESP 2013); 34. Digital water bath (R$ 1,600 – FAPESP 2013); 35. Freezer (R$ 1,600 – FAPESP 2014); 36. Stereomicroscope C-os – Nikon Instruments Inc. (R$ 7 thousand – FAPESP 2014); 37. Precision balance (R$ 2 thousand – FAPESP 2014); 38. Electrophoresis tank (R$ 1,465 – FAPESP 2014); 39. Minicentrifuge (R$ 840 – FAPESP 2014); 40. Vortex (2 x R$ 637 – FAPESP 2014); 41. Microwave (R$ 560 – FAPESP 2014); 42. MINI-V Vertical Laminar Flow Cabinet – Telstar (R$ 13 thousand – CNPq 2015); 43. Real-Time PCR System – LightCycler 96 – Roche (R$ 90 thousand – FAPESP 2015); 44. Magnetic stirrer with heating (R$ 1,700 – FAPESP 2014); 45. Photopolymerizer Bluephase G2 Ivoclar (R$ 5 thousand – FAPESP 2014/17878-1); 46. Dell i7 Notebook (R$ 5,200 – FAPESP 2014/17878-1); 47. Micro-homogenizer (R$ 2,850 – FAPESP 2016); 48. Mini plate spinner (R$ 3,350 – FAPESP 2016); 49. MCA 1-14K Centrifuge – Sigma (2 units) (R$ 63,500 – FAPESP 2016); 50. Micropipettes (R$ 12,690 – FAPESP 2013/2014); 51. 6400RPM Bivolt Minicentrifuge (R$ 1,099.00 – FAPESP 2016/12758-3); 52. ChiroPro implant motor – Gnatus ®ï¸ (R$ 10,350 – RT Institutional Grant Process 2015/13894-5).

3. Cellular and Molecular Biology Laboratory : divided into three subareas: (1) cellular biology, (2) molecular biology, and (3) oral and infectious agents. These laboratories work in harmony to develop research in the various clinical and basic areas of the Program. Examples include the study of cellular and tissue physiology and biochemistry ( in vitro , animal studies, and clinical studies) to understand molecular mechanisms and their subsequent application in the medical and biotechnological areas. The study of these biological models, with or without infectious agents, provides answers to questions about biomaterials , toxic and infectious agents, antioxidants, drugs, and pathological and physiological conditions, for subsequent characterization in specific equipment.
In addition to consumables, benches and other basic facilities, the laboratory has the following equipment:
Acquired in the 2021–2024 four-year period :
1. FTIR spectrophotometer model iS50 – Thermo Fisher Scientific (USA) (US$ 70,630.51/R$ 349,416.20 – FAPESP EMU Grant – Multiuser Equipment 2023/05652-8; 2. Programmable sonicator , FISH-FB120110 Model 120 – Fisher Scientific (USA) (US$ 3,150 – FAPESP 2022/04770-4); 3. Rotary mixer for tubes, BENCH-r5010 1.5/2.0/15/50 ml – Benchmark Scientific (USA) (US$ 1,116.02 – FAPESP 2022/04770-4); 4. OPTI-CB5 – B5 camera, 5.1 MP, Optika Microscopes (USA) (US$ 368.09 – FAPESP 2022/04770-4); 5. OPTI-M620 – Adapter with microscope mount (US$ 180.91 – FAPESP 2022/04770-4); 6. Ultrafreezer -86 °C INDREL – Model IULT 335D (R$ 31,800 – FAPESP 2022/04770-4); 7. Genomic sequencer NANO-MINION BASIC PACK – Nanopore Technologies (USA) (US$ 1,250 – FAPESP 2022/04770-4).
Acquired until 2021 :
1. MAGpix ( Luminex Corporation); 2. Tube shaker, autoclaves (Phoenix); 3. Analytical balance ( Gehaka ); 4. Class II A1 cabin for handling microorganisms ( Pachane ); 5. Digital camera for gel “ photodoc ” (SP 500-UZ – Olympus); 6. Excelsa Baby I centrifuge (Fanem); 7. Refrigerated centrifuge (5804R – Eppendorf ); 8. TE2755 distiller ( Tecnal ); 9. Three bacteriological incubators (two 502 – Fanem and one AL510 – American Lab ); 10. Two sterilization incubators (AL500 – American Lab ); 11. Two electrophoresis sources (EPS301 – Amersham Biosciences ); 12. Four upright freezers (240 – Brastemp); 13. Five refrigerators (411L – DF48 – Electrolux); 14. Fume hood with LCD display for gel documentation (Feldman Wild Leitz ); 15. CO 2 incubator (TE399 – Tecnal ); 16. Ice machine (EGE160 – Everest); 17. Three orbital shaking tables (TE141 – Tecnal ); 18. Microcentrifuge ( MiniSpin Plus 5453 – Eppendorf ); 19. Trinocular microscope ( PrimoStar – Zeiss ); 20. Phase contrast and fluorescence microscope ( Axiovert 40C – Zeiss ); 21. Two horizontal mini-cuats for electrophoresis (HE33 – Amersham Biosciences ); 22. Microwave (NHS56BH – Panasonic); 23. Micropipettes (FAPESP 06/61171-3), five of 0.5–10 µL ( Finnipipette – Labsystems , epResearch 10 – Eppendorf , Microman M10 – Gilson), four of 10–100 µL ( epResearch 100 – Eppendorf and epResearch 2100 – Eppendorf ), four of 100–1,000 µL ( epResearch 1000 – Eppendorf and epResearch 2100 – Eppendorf ), two of 2–20 µL ( Pipetman P200 – Gilson), two of 30–200 µL ( Pipetman P200 – Gilson), two of 250 µL ( Pipetman F250 – Gilson), two of 1,000 µL ( Pipetman F1000 – Gilson), one of 10–50 µL (3002 – Oxford), one of 200–1,000 µL (3004 – Oxford); 24. Multichannel micropipette (eight channels 5–500 µL – Boeco ); 25. Photo/UV transilluminator 21 (3-3025 – Fotodyne ); 26. Reverse osmosis and Milli -Q ( Direct Q3 – Millipore); 27. Microprocessor-based benchtop digital pH meter (PG1800 – Gehaka ); 28. Pipet-Aid ( Midi Plus BioHit – FAPESP 06/54343-2); 29. Fixed-angle rotor (30 tubes of 1.5–2 mL and six tubes of 85 mL F45-30-11 – Eppendorf ); 30. Gel analysis system ( GelQuant v2.7 – Bio-Imaging Systems); 31. Two thermocyclers ( Mastercycler and Mastercycler Gradient – Eppendorf ).

4. Bioterium and Experimentation and Animal Behavior Laboratories : the bioterium is intended for experiments with rats, mice, fish and aquatic invertebrates. With an initial investment of approximately US$ 200 thousand, it was structured with rooms for carrying out experiments, behavioral analysis, surgery, perfusion, pathology, cell culture, cytometry ( Accuri ), study of infectious diseases, image analysis and support rooms for teachers, students and technicians. The bioterium at UNIP is the SPF ( Specific) model. Pathogen Free ), as internationally established in terms of quality. To meet these specifications, UNIP invested approximately US$ 300 thousand in equipment and infrastructure. The technical and administrative infrastructure of the vivarium is prepared to receive and maintain the animals during the experimental period and is in accordance with the guidelines established by CONCEA, which allows compliance with all requirements for research with experimental animals, with a view to their well-being. The vivarium has equipment such as laminar flow cabinets specific for protocols with genetic material, thermocyclers , CO2 incubators , refrigerated incubators, thermoblocks , thermostated baths , pH meter, refrigerated centrifuge, ice machine, ELISA reader, specific flows for research with fungi and bacteria, incubators, BOD, refrigerators and freezers, microscopes, centrifuges, scales, among other equipment necessary for a level 2 safety laboratory. More recently, instruments measuring murine vocalization , microisolators ( Techniplast ) specific for keeping rats and mice in environments with controlled temperature and humidity, equipment for behavioral analysis, such as different arenas for motor, anxiety, depression tests, among others; video cameras, monitors and Noldus-Observer software , photomicroscope (Nikon) and Metamorph image analyzer (Molecular Devices ) were incorporated into the equipment park.

5. Biodiversity Research Center ( NPBio ) of UNIP : in 2007, the Program established a partnership with NPBio in order to diversify research activities. Projects are developed with extracts of Brazilian plants, mainly from the Amazon Rainforest and the Atlantic Forest, and, more recently, with plant species from Antarctica. This Center includes the Extraction, Antitumor Screening, Cell Culture, Microbiology, Chemistry of Natural Products Laboratories and the UNIP Herbarium, all located in São Paulo, and the Plant Processing Laboratory, located on the Manaus campus. The Biodiversity Research Center uses a boat owned by UNIP to conduct field expeditions. The UNIP Herbarium is registered with the Index Herbariorum , an important international entity that regulates activities in the area. The equipment of the Antitumor Screening Laboratory, as well as the consumable material used in the experiments, were financed by FAPESP (US$ 104,525.97). It is worth noting that all collection of botanical material carried out by researchers at the Extraction Laboratory is carried out with a license issued by the Brazilian Institute of the Environment and Renewable Natural Resources (IBAMA, Ministry of the Environment) and by the Genetic Heritage Management Council ( CGen ), and that all biological or chemical tests with extracts obtained from plants collected in conservation units are performed under a license for access to genetic resources (MP No. 2,186, of September 2002), which legitimizes the research work carried out by the Institution. Although access to genetic resources and all collections carried out by UNIP are done with the aforementioned authorizations, today all collection material is being entered into SisGen , the national registry of access to genetic resources, in accordance with new government guidelines (Decree No. 8,772, of May 11, 2016).
5.1. Extraction Laboratory : designed to obtain plant extracts from plants in the Amazon and Atlantic Forest regions, which will be evaluated for their therapeutic properties, based on in vitro and in vivo studies . The laboratory has the following equipment: Walk -In hoods; knife mill (Thomas); an oven with air circulation (Fanem); two analytical balances ( Ohaus and Mettler ); an electronic balance (Marte); a Milli -Q water purification system (Millipore); five rotary evaporators ( Buchi ); a vacuum pump (Edwards); an ultrasonic bath; a manifold for drying samples; a chiller coupled to the rotary evaporators ( Neslab ); a -20 °C cold chamber; a -70 °C freezer ( Revco ); and two tray freeze dryers ( Virtis and Labconco ).
5.2. Microbiology Laboratory : intended for analyses related to the identification of plant extracts active against bacteria of importance to humans and animals, particularly those used in dentistry. The laboratory has two temperature-controlled incubators (Fanem and De Leo); a laminar flow chamber ( Veco ); an optical microscope ( Zeiss ); a micro-library of microorganisms: Staphylococcus aureus, Streptococcus mutans , Streptococcus sanguinis, Enterococcus faecalis , Candida albicans , Escherichia coli, Pseudomonas aeruginosa , Porphyromonas gingivalis and Prevotella intermedia; six multichannel variable volume micropipettes ( Mettler and Eppendorf ); one automatic pipettor ( Eppendorf ); two domestic refrigerators (Electrolux); one microwave (GE); three desiccators; anaerobic systems; one turbidimeter ; pH meter ; and consumables and glassware.
Phytochemistry Laboratory : intended for fractionation and purification of substances from plant extracts. The laboratory has: a plate preparer; a UV-VIS spectrophotometer ( Femto ) coupled to a computer; glass chromatographic columns of various sizes; specific reagents; two hoods; silica for chromatoplates and columns; Sephadex LH20; silica C-18 for columns; HPLC syringes ( Phenomex ); glassware; solvents; reagents; three magnetic stirrers with heating; UV development lamp 254 and 366 nm ; hair dryer; capillaries; a high-performance analytical liquid chromatograph ( Agilent ), and a gas chromatograph ( Agilent ).
5.4. Antitumor Screening Laboratory : intended for cytotoxicity assays to identify extracts that inhibit the growth of human tumors, in vitro , according to international standards. The laboratory equipment, as well as the consumables used in the experiments, were financed by FAPESP (amount: US$ 104,525.97). The laboratory has a centrifuge ( Eppendorf ); a refrigerator (Electrolux); a freezer (Electrolux); a 96-well microplate reader ( Biotek ); a 96-well microplate washer ( Biotek ); an automatic pipettor ( Eppendorf ); two multichannel micropipettes ( Biohit ) and Eppendorf pipettes ; a liquid nitrogen cylinder; an optical microscope ( Zeiss ); an inverted microscope ( Zeiss ); a double incubator (Forma); a BL-2 laminar flow chamber (Forma); a pH meter ; a microplate shaker and consumables.

6. Postgraduate Dental Clinic : intended for clinical research and patient care. The clinic, which is air-conditioned, has 20 fully equipped dental offices, as well as implant motors, a clinical microscope, a CT scanner, a digital X-ray machine and all the basic infrastructure for its operation.

7. Oral Cancer Detection and Prevention Center (CDPCP) : has a fully equipped dental office, suitable for surgical procedures for diagnosis and treatment, as well as equipment for filming and recording interventions, with the possibility of live transmission to the theater, amphitheater and/or undergraduate and postgraduate classrooms. The CDPCP was developed through a partnership with the “Head and Neck Surgery” Discipline of the Paulista School of Medicine (EPM – Unifesp) and allows diagnosed cases to be referred directly to this specialized oncology service. This facilitates access to care, reduces waiting times and gives patients much better chances of cure and quality of life. At the CDPCP, undergraduate and postgraduate students work under the guidance and supervision of professors from the Program, developing not only assistance activities, with great social impact, but also scientific initiation and postgraduate research.

8. Dental Laser Center : contains a high-power Nd :YAG laser (FAPESP 95/05322-6) and four low-power devices ( GaAl As Diode ; Diode associated with LED), which are used in clinical research, in vitro research and patient care.

9. Surgical Center : has rooms equipped for procedures with intravenous or nitrous oxide sedation, changing rooms for patients and professionals, purging and antisepsis rooms, as well as equipment for filming and recording interventions, with the possibility of live transmission to the theater, amphitheater and/or postgraduate and undergraduate classrooms.

10. Sterilization Center with autoclaves and ovens .

11. CEAPE – Center for Studies and Care for Special Patients : has dental equipment and is a reference for referring patients seeking the STD-AIDS Program of the City of São Paulo. The Center also cares for patients with other special needs and conducts clinical research.

12. Laboratories of the More Identity Institute (unip.br/cursos/pos_graduacao/strictosensu/laboratorios/mais_identidade.aspx)
12.1. Digital Laboratory for Prosthesis Production: This laboratory has 3D printers, scanners and state-of-the-art computers, allowing the creation of facial and intraoral prostheses with high precision. Using models obtained through digital photographs, it is possible to sculpt personalized prostheses, facilitating care for patients in different locations, including remotely.
The prostheses are digitally modeled from scanned images , ensuring a perfect fit and greater comfort for the patient.
The technology used enables a more agile and personalized process, in addition to reducing costs and optimizing resources.
12.2. Conventional Prosthesis Laboratory: Although digital technology has revolutionized the production of prostheses, the conventional laboratory is still essential for the refinement and completion of the pieces.
Here, professionals perform manual adjustments and personalized finishes, ensuring the aesthetics and functionality of the prostheses.
This team works in an integrated manner to offer complete rehabilitation, promoting aesthetic and functional recovery, in addition to social reintegration.
They are also responsible for guiding patients on how to care for their prosthetics and adapt to their new look.
12.3. Photography and Scanning Laboratory (Color- Room ): This space is one of the most innovative in the Institute, being essential for the planning and execution of facial prosthetics using digital technology.
The room is equipped with advanced image capture systems, ensuring that every anatomical detail is faithfully reproduced on the prosthesis.
Digital scanning allows for detailed planning, enabling the production of prosthetics with an extremely natural appearance and personalized for each patient.
12.4. Teaching and Training Laboratory: Focused on the education and training of professionals in rehabilitation techniques, this laboratory also promotes scientific exchanges and workshops, contributing to the continuous updating and improvement of professionals in the field.
12.5. Care Clinics : Care clinics are equipped for patient consultations and assessments, allowing detailed monitoring throughout treatment.
They have a multidisciplinary team made up of dentists, doctors, speech therapists, psychologists, nurses, physiotherapists, social workers and nutritionists.
In addition to clinical support, these rooms provide guidance to patients on how to care for their prostheses and adapt to their new look.
12.6. Surgical Center : The Institute has a surgical center prepared to perform oral and maxillofacial rehabilitation procedures .
It is in this environment that facial reconstruction surgeries and the installation of bone-integrated implants take place .
The modern structure allows for safe and effective procedures to be carried out, which are essential for the functional and aesthetic recovery of patients.
These laboratories and clinical spaces are essential for Instituto Mais Identidade to achieve its mission of offering high-quality aesthetic-functional rehabilitation, promoting the recovery of self-esteem and the social reintegration of patients.

Equipment: Fourier Transform Infra-Red Spectrometer (FTIR)

Brand: ThermoFischer

Model: IS50

Origin: Foundation for Research Support of the State of São Paulo (FAPESP)

Responsible Researcher: Adriano Fonseca de Lima

Description
Fourrier Transformed Infra-Red Spectrometer is a device used for the characterization of materials and analysis of chemical reactions, both of solid and liquid materials, by obtaining mid- and near-infrared spectra.

Equipment Location
Research Laboratory of the Paulista University - Rua Dr. Bacelar 902.

Equipment Use
To use the device, it is necessary to make an appointment in advance via email: pgodonto@unip .br. It is important to emphasize that the scheduling is subject to the availability of the team responsible for the equipment.

The Program has maintained national and international exchanges, generating technical and bibliographic productions from these partnerships. The scientific output resulting from the exchanges can be observed in the complete papers published, accepted or submitted for publication, which include the names of the partnership participants.

Partnerships and National Exchanges

1. SÃO PAULO CITY GOVERNMENT: Stricto Sensu Post-Graduation Program in Dentistry, through CEAPE – UNIP (Centre of Studies and Special Patients Services) in partnership with the City’s STD/AIDS Program, provides support to the municipality’s 15 specialized centres (north, south, east, west, and mid-west) for diagnosis and treatment of opportunistic mouth diseases. The population of patients served at the STD/AIDS Program’s reference centres is close to 9,000 users. In addition, patients from several institutions and associations (Support Houses, NGOs, Green Cross, APAE, and others) are also taken to the CEAPE. Researches resulting from this partnership have already been presented at several international conferences in other countries, such as Canada, the USA, Germany, Spain, Portugal, Sweden, Austria, and studies have also been published in national and international journals. The activities are reported in the Social Insertion section.
2. UNIFESP – DEPARTMENT OF MAXILLOFACIAL SURGERY: this partnership allows full service to oncological patients and the Centre is responsible for the application of educational-preventive methods, as well as diagnosing and – in the event of disease detection – carrying out the needed local procedures and forward the case to UNIFESP for a systemic treatment. Also, explanatory self-examination manuals have been developed by students from the Program, and they are distributed to all patients seeking services at UNIP’s clinics. Professor Dr Luciano Lauria Dib coordinates the Maxillofacial Rehabilitation Centre for UNIFESP Head and Neck Surgery Department. In this centre, outpatient and surgical services are available for patients with oncological facial deformities, where they go through rehabilitation procedures with facial implants and prosthesis. Part of this assistance is carried out during UNIP’s Dentistry Course, with the Post-Graduation’s Facial Rehabilitation Clinic. The discipline of Maxillofacial Rehabilitation of UNIP’s Strictu Sensu Post-Graduation Program in Dentistry (MSc level) is carried out at UNIFESP’s outpatient facility, with UNIP students who join the meetings and the clinical activities. Several publications have come out of this partnership with the co-authorship of Professor Marcio Abrahão, Director of UNIFESP’s Otorhinolaryngology Department. The activities performed at this centre allowed the creation of the “More Identity Institute” (“Instituto Mais Identidade”), a Civil Society Public Interest Organization (OSCIP) devoted to free services to patients who suffer from maxillofacial deformities, which represent a strong social impact. A place where several community preventive and clarifying events will be organized.
3. SÍRIO-LIBANÊS (HOSPITAL)– EXTRACTION LABORATORY: covenant with the Research and Teaching Institute of Sírio Libanês Hospital (IEP-HSL) for supplementary studies carried out in the area of natural products by UNIP’s extraction Lab. There is a project in progress called "Rio Negro Project", coordinated by researchers Dr Riad Naim Younes, Dr Antonio Drauzio Varella, both from UNIP, and by Dr Luiz Fernando Lima Reis, from IEP-HSL, and counts with on researchers Dr Ivana Barbosa Suffredini, Dr Ingrit Elida Collantes Díaz (Peru), and Dr Mateus Luís Barradas Paciencia, from UNIP. The project is also jointed by IC’s students, master’s candidates, and doctoral candidates. The researchers listed in this group, apart from the ones from IEP-HSL, from UNIP, and other external collaborators, occasionally meet and discuss project-related matters.
4. RIO GRANDE DO NORTE’S HEALTH SECRETARIAT: in partnership with the Clinic of maxillofacial rehabilitation, Professor Dr. Luciano Lauria Dib travels to Natal (RN), three times a year, to perform surgeries on patients from the Unified Health System (SUS), for fixation of bone-integrated implants on patients having severe facial and maxillary deformities of oncological treatment origins. These implants are used for retention of rehabilitating facial prosthesis. The ongoing project serves patients and provides prosthesis maintenance support. Social Insertion: These activities completely change the State community, as they allow the patients’ social reintegration, delivering conditions for them to resume family coexistence, labour activity, and human dignity recovery.
5. KIDNEY AND HYPERTENSION HOSPITAL/UNIFESP: UNIP’s Strictu Sensu Post-Graduation Program in Dentistry, through Professor Dr Élcio Magdalena Giovani, jointly with the undergraduate course, through CEAPE (Centre of Studies and service to Special Patients), in partnership with UNIFESP’s Kidney and Hypertension Hospital, provides support to the patients with chronic kidney insufficiency – pre- and post-transplanted - acts in the prevention of the mouth health integrity, prepares them for surgery and avoids infectious processes in post-surgery maintenance, as these are the most aggravating conditions for transplanted organ rejection, besides early detection, diagnosis and treatment of mouth opportunistic manifestations. Every semester, the Hospital’s medical team holds a workshop for qualification of UNIP’s undergraduate course students, apart from taking part in the discussion of these students’ clinical cases that occurred at the hospital, which fosters the preparation of partnership research projects. The Gold Standard Hospital is an extremely relevant reference centre for science. Last year, there were 1,030 transplantations performed in the institution (the largest number for an single institution in the world), with high success rates and minimum rejection level. Several research projects have been developed through this partnership, and courses are taught to the students as part of UNIP’s undergraduate course Continuous Education Program. This course is joined by undergraduate students, those from UR (Undergraduate Research), and from graduation (specialization, Master’s, and PhD Degrees). Research works related to this partnership have been presented in national and international conferences, and an article has been accepted for publication, with three more on the way (ongoing research).
6. PREMIER HOSPITAL: this rich partnership refers to the exchange of experiences in dental intervention practices and research in patients under palliative care. This hospital has cared for patients in excellent human dignity conditions, most of them elderly with the most varied degrees of immobility owing to their pathologies and/or young people who had accidents (quadriplegic/coma, etc.). The undergraduate students, those from the UR and from the graduation Programs (specialization, Master’s, and PhD Degrees) supervised by Professor Dr Elcio Magdalena Giovani, perform clinical intervention and research. There are three researches in progress.
7. USP’S MATHEMATICS AND STATISTICS INSTITUTE: the Program’s professors keep partnership with professors from the Institute of Mathematics and Statistics, part of USP’s Department of Statistics, aiming at expanding the analyses and optimizing the data obtained through UNIP’s developed studies.
8. USP’S SCHOOL OF MEDICINE: partnership between faculty members Professor Dr Luciano Lauria Dib and Professor Dr Marcio Z. Casati with the CLINIC OF AUTOIMMUNE DISEASES (Dermatology Subject segment of USP’s College of Medicine). This partnership seeks to produce scientific research projects on vesiculobullous diseases and mouth manifestations, with the participation of our students and Professors. In 2018, the following article was published: Migliorini, Sergio Eduardo, Pecorari, Vanessa Gallego Arias, Casati, Marcio Zaffalon, Santi, Claudia Giuli, Neto, Cyro Festa; Dib, Luciano Lauria (authors). “Oral Manifestations, Gingival Index, and Dental State of Vesiculobullous Diseases”. International Journal of Clinical Medicine. v. 09, p. 408-422, 2018.
9. DEPARTMENT OF MANAGEMENT AND INFORMATICS ON HEALTH FROM THE FEDERAL UNIVERSITY OF SÃO PAULO: partnership established through Professor Dr Cristina Feijó Ortolani, for the development, conception, and design of applications in the Dentistry area. At UNIP, the Research Group ‘Informatics in Dentistry’ was created with the participation of faculty members and master’s and PhD candidates, and RU from both institutions. It is the only Research Group in this area in Brazil. The results of this partnership have been presented in national and international conferences, with six articles already published and three articles submitted in 2018 awaiting publication. Three applications are being developed: one for child mouth health prevention, one for patients with microcephaly, and one for teenage patients during orthodontic treatment.
   Education and Cyberculture is another discipline that is offered at UNIFESP by Professor Dr Cristina Feijó Ortolani to students of both Universities as part of this partnership. She has also participated in examination boards of projects and presentations of master’s degree dissertations and doctorate theses.
10. UNIVERSITY ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO - UNESP - SÃO JOSÉ DOS CAMPOS: through Professor PhD. Alberto N. Kojima, faculty member of UNESP’s Department of Dental Materials and Prosthesis, studies have been carried out in the area of Extensometry – Mechanical Assays of Dental Materials, with collaboration of Professor Dr Alfredo Mesquita. This partnership has already generated a project approved before FAPESP, works presented in research conferences, according to the authors’ Lattes Curriculum; three articles in international, multicentre journals, jointly published with Professor Mutlu Ozcan (University of Zurich).
11. FEDERAL UNIVERSITY OF ABC: partnership established by means of Professor Dr Maria Martha Bernardi with the Centre of Cognition and Complex Systems and Graduate course in Biotechnology from the Federal University of ABC for the development of connected to obesity and reproductive aspects-related research. This partnership has allowed the establishment of a Lab of Behaviour and Molecular Biology at UFABC for joint works with UNIP.
12. THE PHARMACOPOEIA GROUP: through Professor Dr Maria Martha Bernardi and Pharmacopeia Cil, Brazil, Pharmaceutical Company. This partnership seeks to study the effects of ancillary phytotherapeutics on weight loss. This partnership was responsible for two technical reports in 2012: “Weight loss in rats fed hypercaloric food and treated with 9611phytotherapy” and “Weight loss in rats fed with hypercaloric food and treated with phytotherapy at different proportions”. Other researches have also been developed.
13. COLLEGE OF VETERINARY MEDICINE AND ANIMAL HUSBANDRY TECHNOLOGY – UNIVERSITY OF SÃO PAULO: with the participation of Professor Dr Maria Martha Bernardi, this partnership seeks to develop research projects, supervision, and co-supervision to graduate students in the area of Development Toxicology. Outcomes of this collaboration were works published in prestigious journals.
14. CENTER OF ENGINEERING, MODELING, AND APPLIED SOCIAL SCIENCES (CECS) FROM UFABC AND UFPE’S DEPARTMENT OF BIOMEDICAL ENGINEERING: with the participation of Professor Dr Maristela Dutra-Corrêa, this partnership established with Professor Dr Patrícia Aparecida da Ana, from UFABC, and Professor Dr Emery C. C. C. Lins, Assistant Professor – UFPE, both with research in the areas of Optics and Biomedical Images with the use of visible and infrared radiations for pathology diagnosing and biomaterials optical characterization, and diagnosis and therapy of mouth and tooth pathologies. One of the outcomes from this partnership was Selma Regina dos Santos Almeida’s PhD Degree, using photonic images for detecting tooth cavities, completed in 2018.
15. EMPRESA CONEXÃO SISTEMA DE PRÓTESES LTD.: cooperation project with Professor Dr Luciano Lauria Dib for the development of a new model of extraoral implant for use in maxillofacial rehabilitation. This project counts with the participation of graduate students.
16. USP’s INSTITUTE OF CHEMISTRY (IQ-USP) AND USP’s SCHOOL OF DENTISTRY (FO-USP): cooperation project, already completed, between Professor Dr Maristela Dutra-Correa and FO-USP, with Professor Dr Igor Studart Medeiros and at IQ-USP, and Professors Dr Koiti Araki and Dr Sergio H Toma, with UNIP’s Extraction Lab, and with Professor Dr Ivana Barbosa Suffredini, for new dental biomaterials development with nanotechnology (silver nanoparticles). This partnership has already led to several abstracts published in events historical records (around 16) and an article published in an high-impact factor International Magazine with participation of a master’s degree student and an UR student. Works completed: 3 Master’s degrees (Ms Catarina Pires Bezerra, Ms Monica de Abreu Pessoa Rodrigues, and Ms Marina Struncová Fernandes), 1 Final Undergraduation Essay (Ms Alessandra Almeida Bráz Varanda Leite) and 3 Undergraduate Researches (Ms Marina Struncová Fernandes, Ms Alessandra Almeida Bráz Varanda Leite, and Ms Gabrielly Caramel Juvino).
17. REGIONAL HOSPITAL OF FERRAZ DE VASCONCELOS “Dr. Osiris Florindo Coelho” – part of the State Health Secretariat. In this hospital, patients with special needs on dental treatment are submitted to dental services under general anaesthesia at the Centre of Studies and Service to Special Patients – CEAPE UNIP. With these patients, it to perform outpatient treatment is impossible due to the varied pathologies they and limitations they present. Services at the Hospital of Ferraz of Vasconcelos are carried out by PNE-specialization students and by master’s and PhD students from the Graduate Program, also assisted by undergraduate students.
18. MARY SPEERS FOUNDATION: Social Inclusion Project for people at risk and vulnerability for residents in the downtown region of São Paulo City; the Program acts on two important pillars: 1. Educational and preventive service to mouth hygiene care on children going to the Foundation’s school, 2. Educational and preventive to buccal health services for the mothers of the same students who attend the Foundation’s school. This project is joined by undergraduate, UR, and graduate students (specialization, Master’s, and PhD Degrees). This partnership’s activities are described in the Social Insertion section.
19. SÃO PAULO STATE UNIVERSITY “JÚLIO DE MESQUITA FILHO” - UNESP – BOTUCATU CAMPUS: cooperation between Professor PhD Denise Carleto Andia (UNIP) and Professors Willian F Zambuzzi and Rodrigo Augusto da Silva, both from the Bio-Sciences Institute, Department of Chemistry and Biochemistry, UNESP, for joint research development in the area of common interest, related to bone layer epigenetic regulation. This partnership counts on collaboration from students from UNIP’s and UNESP’s Strictu Sensu Graduate Programs.
20. STATE UNIVERSITY OF CAMPINAS – FOP: Professors who teach Periodontics in the Program keep a partnership with professors from UNICAMP for the development of joint researches, especially projects linked to the areas of Microbiology, Molecular Biology, and Periodontics. There is also collaboration between Professor Dr Denise Carleto Andia (UNIP) and the Periodontics area of FOP/UNICAMP’s Prosthesis and Periodontics Department for development of the project named “Epigenetic regulation of human mesenchymal cells”, from Young Researcher Aid under the supervision of Professor Dr Denise Carleto Andia (FAPESP – 2013/09650-8). This partnership counts on the collaboration from Master’s and UR students from FOP/UNICAMP’s Graduate Program.
21. IPEN – CNEN/SP: cooperation carried out through Profa. Cintia Helena Coury Saraceni, with Profs. Denise Zezell and Ricardo Samad from the Center for Lasers and Applications – IPEN-CNEN/SP, with the aim of carrying out research with the Femtosecond laser on ceramic structures. The partnership was signed in 2016 and generated two completed PhD and one master's degree research. Doctoral research is underway, scheduled for completion in December 2023.
22. SÃO PAULO STATE UNIVERSITY “JÚLIO DE MESQUITA FILHO” - UNESP – ARAÇATUBA CAMPUS: partnership settled by faculty Professors of the Periodontics Program’s for the immunohistochemistry analyses of samples coming from Project “Role Of Resveratrol in the Control of Bone Alterations Associated to Osteoporosis: Study on Ovariectomized Rats”, jointly with Professor Dr Edilson Ervolino.
23. SÃO PAULO STATE UNIVERSITY “JÚLIO DE MESQUITA FILHO” - UNESP – ARARAQUARA CAMPUS: partnership established by faculty Professors of the Periodontics Program’s for MICRO-CT analyses of samples originating from Project “Impact of Resveratrol at Risk Conditions: Evaluation of the Bone Repair and Induced Experimental Periodontitis Processes on Diabetic Rats Exposed to Cigarette Smoke”, a joint work with Professor Dr Adriana Marcantonio.
24. PRESBYTERIAN UNIVERSITY MACKENZIE - established with the support of Professor Dr Maria Martha Bernardi, this partnership aims at developing research projects and co-supervision to graduate students in the area of Development Disorders. This collaboration has already brought results and studies have been published in high-impact journals.
25. UNIVERSITY OF SÃO PAULO’s SCHOOL OF DENTISTRY – RIBEIRÃO PRETO CAMPUS: faculty Professors of the Program keep a partnership with professors from FORP-USP for joint-research development, especially regarding evaluations in computerized micro-tomography for bone repair evaluation. This partnership made it possible to publish the article: (authors) Cirano FR, Pimentel SP, Casati MZ, Corrêa MG, Pino DS, Messora MR, Silva PHF, Ribeiro FV. “Effect of curcumin on bone tissue in the diabetic rat: repair of peri-implant and critical-sized defects”. Int J Oral Maxillofacial Surg. 2018 Nov; 47 (11): 1495-1503. doi: 10.1016 / j.ijom.2018.04.018. Epub 2018 May 29. PubMed PMID: 29857981.
26. SÃO LEOPOLDO MANDIC SCHOOL OF DENTISTRY: partnership through Professor Dr Marcelo Napimoga, who took part in the histological evaluation of joints of the animals in the following research: (authors) Corrêa MG, Pires PR, Ribeiro FV, Pimentel SP, Cirano FR, Napimoga MH, Casati MZ, Casarin RCV. “Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats”. PLoS One. 2018 Oct 3; 13 (10): e0204414. doi: 10.1371 / journal.pone.0204414. eCollection 2018. PubMed PMID: 30281626; PubMed Central PMCID: PMC6169914.
27. PIRACICABA SCHOOL OF DENTISTRY – UNIVERSITY OF CAMPINAS: partnership established by Professor Dr Renato Casarin wo, along with professors and students from UNIP’s Strictu Sensu Graduate Program, enabled the analysis of the microbiome of patients who smoke and bear dental implants. This partnership has generated the following publication: (authors) Pimentel SP, Fontes M, Ribeiro FV, Corrêa MG, Nishii D, Cirano FR, Casati MZ, Casarin RCV. “Smoking habit modulates peri-implant microbiome: A case-control study”. J Periodontal Res. 2018 Dec; 53 (6): 983-991. doi: 10.1111 / jre.12597. Epub 2018 Sep 26. PubMed PMID: 30259511.
28. FEDERAL UNIVERSITY OF RIO GRANDE DO SUL’s SCHOOL OF DENTISTRY: the Program’s professor and students keep research partnership with Professor Dr Alex Haas for research development in the area of peri-implantitis. Out of this partnership, a recent study has been published: (authors) Pimentel SP, Fontes M, Ribeiro FV, Corrêa MG, Nishii D, Cirano FR, Casati MZ, Casarin RCV. “Smoking habit modulates peri-implant microbiome: A case-control study”. J Periodontal Res. 2018 Dec; 53 (6): 983-991. doi: 10.1111 / jre.12597. Epub 2018 Sep 26. PubMed PMID: 30259511.

Internationalization

By means of institutional exchange programs, UNIP’s internationalization process is growing strong, both with the development of joint researches – with students coming from Latin American institutions outside Brazil – and with faculty and student mobility.

Faculty/Student Mobility

The partnerships established in 2014 between Professors Dr Adriano Fonseca de Lima and Dr Flávia Pires Rodrigues, from UNIP, with Professors Dr William Palin from the University of Birmingham and Dr David Watts from the University of Manchester has ongoing and continuous research. One of them was the work of title "Influence of different polymerization initiation systems on the chemical-physical properties of experimental resins", partially funded by CNPq through PIBIC scholarship for our student, Mr Marcos Vinícius Salvador, awarded as the best undergraduate research in the Area of Health Sciences at the XVII Scientific Meeting, the 19^th Scientific Initiation Meeting and UNIP’s 4^th Technological Initiation Meeting.

Professor Dr. Denise Carleto Andia also participated in this program with the Institute for Biomedical Research (IBR), Cancer Sciences, University of Birmingham (UoB), Birmingham, in partnership with Professor. Malgorzata Wiench. Professor. Denise Carleto Andia was in Birmingham from May to July 2015 developing the project: "RG108 demethylating therapy in head and neck squamous cell carcinoma: the impact on DNA methylation and hydroxymethylation."

In 2017, there was also the visit of the PhD student Ms Anna Larsson, supervised by Professor Ulf Nannmark from the University of Gothenburg for experiments related to her project. The student's participation was part of our student mobility actions that resulted from the partnership established by UNIP’s Graduate Program in Dentistry and the University of Gothenburg.

TRAINING COURSE IN CUBA: Since 2015, a partnership has been in force between the UNIP’s Graduate Program and the Latin American Society for Face Rehabilitation and Bucomaxilofacial Prosthesis. Professor Luciano Dib, along with PhD student Mr Rodrigo Salazar Gamarra (Peru), carried out training courses for the rehabilitation of patients with trauma and tumours deformities at the Centro de Prótesis Bucomaxilofacial, Hospital CIMEQ, Havana/Cuba. The lecturer and PhD candidate holds the positions of president and secretary of the Board of Directors of the Company.

INTERNATIONAL STUDENTS: UNIP’s Graduate Program in Dentistry also participates in the internationalization process, receiving students from Latin America. There are three Peruvian students enrolled in the Program. One of them, Mr Rodrigo Salazar, has already presented his master’s dissertation and is now a PhD student. His work, under the supervision of Professor Luciano Dib, has already been published and has a strong social impact, as it aims at the post-surgical prosthetic rehabilitation of cancer patients through a 3D-protocol that eliminates moulding steps and decreases the final prosthesis cost. The work had national and worldwide impact and a series of interviews was carried out with the student and the professor at UNIP.

Two other Peruvian students presented their master’s dissertation in 2017, both in the Prosthesis sub-area, and one of them initiated the PhD graduation, and a new student began her master's degree in 2018.

In compliance with the established goal to increase Program internationalization, in 2017, English language courses started being offered.

Part of the Program’s internationalization process can be characterized by the international partnerships and exchanges mentioned below:

Partnerships and International Exchange

1. UNIVERSITY OF GOTHENBURG/SWEDEN: the international exchange remains with fellows visits from both Universities. In 2018, with Ms Anna Larsson and Professor Ulf Nannmark, researches were developed in the area of extraoral implantology, with in vivo experiments performed and collected at UNIP School of Dentistry and sent to the University of Gothenburg for microscopic analysis. These experiments generated publications that are now in the final writing phase. The following article was also published as result of this partnership: (authors) De Oliveira FM, Salazar-Gamarra R, Öhman D, Nannmark U, Pecorari V, Dib, LL. “Quality of life assessment of patients utilizing orbital implant-supported prostheses”. Clinical Implant Dentistry and Related Research, v. x, p. x, 2018.
2. UNIVERSITY OF ZURICH / SWITZERLAND: Through Professor Alfredo Mesquita and Professor Mutlu Özcan from the Department of Dental Biomaterials of the University of Zurich, this partnership involves the exchange of knowledge in the areas of implantology and dental materials, with focus on dental ceramics. This partnership, along with the one with UNESP São José dos Campos, keep on bringing results. Article published in 2018: (authors) Moura RV, Kojima NA, Saraceni CHC, Bassolli L, Balducci I, Özcan M, Mesquita AMM. “Evaluation of the Accuracy of Conventional and Digital Impression Techniques for Implant Restorations”. Journal Of Prosthodontics.
3. UNIVERSITY OF ZÜRICH AND DEPARTMENT OF MORPHOLOGY AND GENETICS OF THE FEDERAL UNIVERSITY OF SÃO PAULO: Partnership for the development of an application named "Integrated Pain Support" for the diagnosis and treatment of temporomandibular dysfunctions., Scientific papers to support the system are under development, as well as a specific electronic medical record for TMJ to be implemented at UNIFESP. The partnership has generated, to date, a published article and a research presentation at an International Conference.
4. UNIVERSIDAD PERUANA CAYETANO HEREDIA – FACULTAD DE ESTOMATOLOGIA ROBERTO BELTRÃN – Área de medicina y patologia oral y maxillofacial / Área de atención estomatológica de pacientes especiales: for exchange between undergraduate and graduate students concerning experiences in handling patients with special needs and patients with oral manifestations.
5. UNIVERSITY OF TORONTO: agreement signed for research in the area of Periodontics, especially aiming at the in-depth study regarding the use of Resveratrol as a modulator of the host response to the presence of periodontal disease and during bone repair processes. As results from this partnership, the following articles were published in journals of relevant impact: (authors) Corrêa MG, Absy S, Tenenbaum H, Ribeiro FV, Cirano FR, Casati MZ, Pimentel SP. “Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation”. J Periodontal Res. 2018 Oct 22. doi: 10.1111/jre.12622. [Epub ahead of print] PubMed PMID: 30346038.
6. UNIVERSITY OF BIRMINGHAM: Partnership signed since 2014 by Professors PhD. Adriano Fonseca de Lima and Flávia Pires Rodrigues for researches related to the evaluation and the development of new resinous compounds, with improvements in both the monomeric part and the initiation systems. The established partnership has been maintained with visits of both professors to the University in England, working along with the Department of Biomaterials, in collaboration with Professors PhD. William M. Palin and Owen Addison, as well as the visit of the mentioned Professors of the University of Birmingham to UNIP. The exchange is financed by both universities through travel funding, which enables the continuous work development, whose result, up to the present moment, consists of two works submitted and still under review, and some works being written in the area of restorative dentistry and dental materials. Professor Denise Carleto Andia, from the area of epigenetic of UNIP’s Strictu Sensu graduate program in Dentistry, also has been working in partnership with Professor PhD. Malgorzata Wiench, researcher of the Department of Epigenetic, Institute of Biological Research, Cancer Sciences, University of Birmingham, since 2015. The partnership allowed the mobility of Professor Denise Carleto Andia to the University of Birmingham with financial costs borne by her Young Researcher Aid (FAPESP 2013/09650-8). During the internship, Professor Denise investigated the epigenetic regulation in tumour cells of spinal cell cancer. The partnership foresees future visits, depending on new funding of development agencies either from Brazil or from the UK, or in partnership with both countries.
7. UNIVERSITY OF ILLINOIS - CHICAGO: Exchange with the Department of Craniomaxillofacial Rehabilitation for the development of a project in the area of digital technology for production of facial prostheses. In November 2018, Professor Rosemarie Sealous, specialist in digital technology, visited UNIP again to teach a course at UNIP’s Strictu Sensu graduate program. The performance of our student Mr Rodrigo Salazar Gamarra, from Peru, under the supervision of Professor Luciano Dib, and in partnership with the University of Illinois, resulted in the creation of a method for the creation of facial prostheses through digital technology with significant impact on the international community, with journalistic articles in the Brazilian and worldwide mass media, in addition to the award by received from MIT as a Humanitarian Innovator for Latin America 2018, for researchers under 35 years of age.
8. UNIVERSITY OF MANCHESTER – ENGLAND: Partnership established in 2015, through Professor Flávia Pires Rodrigues, which studies resinous materials used in Dentistry, with the support of Professor David Watts. The evaluation of the chemical and physical properties of these materials resulting from modifications in the processes of polymerization initiation was effected for the acquisition of materials with better performance. Some articles resulting from the partnership were published at Dental Materials and Brazilian Oral Research journals, and others are being written for subsequent submission. One of them results from the master’s degree dissertation presented by Ms Karina Verzola, supervised by Professor Adriano Fonseca de Lima.
9. UNIVERSITY OF WESTERN ONTARIO: In 2016, a partnership was established between Schulich Dentistry, Dep. of Biochemistry, London, Ontario, Canada, with Professor Walter Siqueira (UNIP) and Professor Alfredo Mikail Melo Mesquita. Professor Walter Siqueira worked from UNIP, funded by the institution, in the design of research projects that are in their implementation phase. One of them is of high social impact and concerns the rehabilitation of AIDS patients from the Centre of Special Patient Care, with Professor Elcio Giovani.
10. EVOLVA (BASEL - SWITZERLAND): Partnership that has made viable the study "Effect of resveratrol on non-surgical periodontal treatment of smokers diagnosed with Chronic Periodontitis. Prospective evaluation of clinical, microbiological, immunological results, and oral neutrophil quantification".
11. OKAYAMA UNIVERSITY, in Japan: a partnership that favours student mobility of the two institutions in the pursuit of knowledge, mainly focused on the area of imaging. This partnership is held between FOUNIP x FOUSP x Okayama. In October 2018, four students were welcomed from the Okayama Dentistry graduate program in , who took part in the Symposium of Patient Care with Special Needs, organized by Professor Elcio M. Giovani; an event that also counted with the presence of two international speakers.
12. Reinstatement of the agreement with the National Cancer Institute, NIH, USA, with the signature of the Memorandum of Understanding in 2018.
13. Establishment of collaboration with the College of Textile and Chemistry Engineering of the Universidad Nacional de Ingeniería, Lima, Peru. As a result of this collaboration with Peru, 7 works have been published, 2 in 2018, 3 in 2017, and 2 in 2016.
14. LATIN AMERICAN SOCIETY OF BUCOMAXILLOFACIAL REHABILITATION: Exchange between UNIP, Instituto Mais Identidade and the society, under the coordination of Professor Luciano Dib, who is the President of the Educational Committee of the Society, responsible for the management and regulation of courses of professional improvement carried out internationally by the society and which will be delivered at UNIP.
15. OREMA FOUNDATION – CHILE: This foundation is a charitable entity from Santiago, Chile, which has partnered with the National Hospital of Cancer of Chile, dedicated to the maxillofacial rehabilitation of oncologic patients. The partnership involving Instituto Mais Identidade, UNIP and OREMA Foundation will allow the development and enhancement of digital technologies with the purpose of surgery planning and execution, and rehabilitation prosthetics. There will be professional exchanges, with courses and internships both in Brazil and in Chile.

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