The PPGO has evolved significantly in its internationalization and continues to work to grow in the various forms of internationalization: multilateral research, dissemination of intellectual production, faculty and student mobility. “Internationalization at home” measures are the responsibility of the Academic Internationalization Office, but the PPGO is internationalizing through: multilateral research, dissemination of intellectual production, a page on UNIP's website in English and Spanish, the reception of foreign professors, the participation of foreign professors on defense boards, the reception of international students with subjects in English, the recruitment of students from Latin America and faculty and student mobility.
1 - Research projects in partnership with foreign institutions
Prospective observational study of SynCone® concept: Patient-related outcomes, clinical, radiographic, immunoinflammatory mediators, and microbiological analysis.
Protocol: I-AN-17-015
Team: Mônica G. Corrêa, Suzana P. Pimentel, Raíssa Micaella Marcello Machado, Fabiano R. Cirano, Márcio Z. Casati.
Students: Marcelo Marinho (master's degree); Sophia (master's degree)
Foreign institution: Dentisply - Mölndal, Sweden.
Amount: R$ 73 thousand
The project was approved by the “Dentsply Sirona Implants' Global IIS Review Committee of Investigator Initiated Studies”. We currently have more than 300 investigators in more than 20 countries. In a pioneering way in Brazil, this support will enable the development of the Program's dissertation/thesis and the presentation of papers at international congresses.
Effect of resveratrol on non-surgical periodontal treatment of smokers diagnosed with chronic periodontitis. Prospective evaluation of clinical, microbiological, and immunological results.
Team: Márcio Z. Casati, Mônica G. Corrêa, Suzana P. Pimentel, Fabiano R. Cirano, Howard Tenenbaum.
Students: Vanessa Luchesi (graduate), Ana Paula Giorgette (post-doc graduate), Bruno B. Benatti (post-doc student)
Foreign institution: Department of Periodontology, Faculty of Dentistry, Laboratory Medicine and Pathobiology, Faculty of Medicine University of Toronto, Toronto, Ontario, Canada and Department of Dentistry, Sinai Health System, Toronto, Ontario, Canada.
Amount: R$ 240,000 Evolva - Reinach - Switzerland.
This project is in the final stages of development and involves two post-doctoral graduates, one of whom is the coordinator of the PPGO at UFMA. It also included the participation of a former IC, master's and doctoral student from UNIP. It is the result of international cooperation between the University of Toronto/Universidade Paulista and received international funding from the company Evolva - Reinach - Switzerland.
Research Grant PNGP - New Generation of Researchers Program / PI - Initial Project
Title: Biocompatibility of new polymerization co-initiators and evaluation of their influence on chemical, physical and biological properties of experimental resins
Process: 2022/02823-3
Duration: 01/02/2023 to 31/01/2026
Amount: R$228,997.95/US$83,614.10
Principal investigator: Adriano Fonseca de Lima
Teaching staff: Denise Carleto Andia (DO) and Jacques Lalevée (PI)
This project, approved under the PNGP/PI Research Grant from FAPESP, is part of an international collaboration with Prof. Jacques Lalevée, one of the world's leading experts in polymerization, linked to the Mulhouse Institute of Materials Science at the Université de Haute-Alsace (France).
This partnership has already resulted in important scientific contributions, including the publication of the article “Novel co-initiators of polymerization: Cytotoxicity profile and modulation of inflammatory mediators in human dental pulp stem cells”, in the prestigious journal Dental Materials. Also noteworthy is the PhD thesis study by Marcos Vinícius de Oliveira Salvador, under the supervision of Prof. Adriano Lima, which was defended at the end of 2024. The article derived from this research is currently being evaluated in the journal Macromolecular Rapid Communications, further consolidating the relevance and scientific impact of the project.
2 - Internationally circulated publications by Program students/graduates in the four-year period
The PPGO's intellectual output is concentrated in qualified journals with international circulation and has shown significant growth in the quality and impact of its scientific output. The Field-Weighted Citation Impact (FWCI), a metric that assesses the impact of citations of articles, researchers, research groups or institutions compared to the global average for the area of knowledge, grew from 1.21 in the previous four-year period to 1.33 in the 2021-2024 period. This index indicates that PPGO-UNIP publications received 33% more citations than the global average for the area, showing not only the quantity, but also the relevance and scientific influence of the Program's academic output.
Student inclusion in qualified production has grown substantially, with participation percentages of 60% in stratum A1; 55% in A2; 60% in A3; 50% in A4. The products with the greatest impact are among the four main productions already mentioned by the professors in item 2.4.1.
3 - Bibliographic (WoS, Scopus), technical and technological production of greater impact authored/co-authored with researchers based in foreign institutions
Caption
CAPITAL LETTER: student/returning student
(DO): teacher
(IC): scientific initiation
(PN): national partner
(PI): international partner
(PD): post-doctorate
UNIVERSITY OF MANCHESTER/BIRMINGHAM
Assis RIF (PN), Wiench M (PI), Ruiz KGS (PN), Silva RA (PN), Feltran G (PN), Sallum EA (PN), Casati MZ (DO), Nociti Junior FH (PN), Andia DC (DO). RG108 increases NANOG and OCT4 in bone marrow-derived mesenchymal cells through global changes in DNA modifications and epigenetic activation. PLoS One. 2018; 13(12): e0207873.
FERREIRA RS, Assis RIF (PN), Racca F (PI), Bontempi AC (IC), da Silva RA (PN), Wiench M (PI), Andia DC (DO). Analysis in silico indicate the lncRNAs MIR31HG and LINC00939 as possible epigenetic inhibitors of osteogenic differentiation in PDLCs. Genes (Basel). 2023;14(8):1649. doi:10.3390/genes14081649.
Assis RIF (PN), SCHMIDT AG, Racca F (PI), da Silva RA (PN), Zambuzzi WF (PN), Silvério KG (PN), Nociti FH Jr (PN), Pecorari VG (DO), Wiench M (PI), Andia DC (DO). DNMT1 inhibitor restores RUNX2 expression and mineralization in periodontal ligament cells. DNA Cell Biol. 2021;40(5):662-674. doi:10.1089/dna.2020.6239.
Dressano D, SALVADOR MVO, Aguiar FHB, Goncalves LS, Palin WM (PI), Watts DC (PI), et al. Achieving property enhancements in dental resin composites via reduced concentrations of camphorquinone within a ternary initiator system. Dent Mater. 2024;40(9):1400-8.
UNIVERSITÉ DE HAUTE-ALSACE
Lima AF (DO), Pizzanelli GG (PI), Stolf CS (PI), Salomon JP (PI), Lalevee J (PI), Andia DC (DO). Novel co-initiators of polymerization: Cytotoxicity profile and modulation of inflammatory mediators in human dental pulp stem cells. Dent Mater. 2024;40(10):1692-6.
UNIVERSITY OF MURCIA/UNIVERSITY OF MICHIGAN/UNIVERSITY OF CHIETI-PESCARA
Gehrke SA (PI), Cortellari GC (PI), DE Oliveira Fernandes GV (PI), Scarano A (PI), MARTINS RG, CANÇADO RM, Mesquita AMM (DO). Randomized Clinical Trial Comparing Insertion Torque and Implant Stability of Two Different Implant Macrogeometries in the Initial Periods of Osseointegration. Medicina 2023;59:168.
UNIVERSITY OF MURCIA
MARTINS RG, CASTRO TSD, Dib LL (DO), Gehrke SA (PI), Mesquita AMM (DO). Influence of Restorative Material on the Distribution of Loads to the Bone in Hybrid Abutment Crowns - In Vitro Study. Medicina (Lithuania). 2023;59:1188-12.
IOWA UNIVERSITY
CANÇADO RM, Sakuno A (PN), Floriani F (PI), Zandinejad A (PI), Saraceni CHC (DO), Giovani EM (DO), Mesquita AMM (DO). Impact of aging on the fracture strength of 3D-printed fixed implant prostheses: A comparative analysis of monolithic and bi-layer with or without fiber-reinforced composite frameworks. J. Prosthodont Implant Esthet Reconstr Dent. 2024. p. 1-8.
4 - Research in partnership with foreign institutions
Caption
CAPITAL LETTER: student/returning student
(DO): teacher
(IC): scientific initiation
(PN): national partner
(PI): international partner
(PD): post-doctorate
UNIVERSIDADE DE BIRMINGHAM
Assis RIF (PN), Wiench M (PI), Ruiz KGS (PN), Silva RA (PN), Feltran G (PN), Sallum EA (PN), Casati MZ (DO), Nociti Junior FH (PN), Andia DC (DO). RG108 increases NANOG and OCT4 in bone marrow-derived mesenchymal cells through global changes in DNA modifications and epigenetic activation. PLoS One. 2018; 13(12): e0207873.
FERREIRA RS, Assis RIF (PN), Racca F (PI), Bontempi AC (IC), da Silva RA (PN), Wiench M (PI), Andia DC (DO). Analyzes in silico indicate the lncRNAs MIR31HG and LINC00939 as possible epigenetic inhibitors of the osteogenic differentiation in PDLCs. Genes (Basel). 2023;14(8):1649. doi:10.3390/genes14081649.
Assis RIF (PN), SCHMIDT AG, Racca F (PI), da Silva RA (PN), Zambuzzi WF (PN), Silvério KG (PN), Nociti FH Jr (PN), Pecorari VG (DO), Wiench M (PI), Andia DC (DO). DNMT1 inhibitor restores RUNX2 expression and mineralization in periodontal ligament cells. DNA Cell Biol. 2021;40(5):662-674. doi:10.1089/dna.2020.6239.
Dressano D, SALVADOR MVO, Aguiar FHB, Goncalves LS, Palin WM (PI), Watts DC (PI), et al. Achieving property enhancements in dental resin composites via reduced concentrations of camphorquinone within a ternary initiator system. Dent Mater. 2024;40(9):1400-8.
UNIVERSITY OF TORONTO
Cirano FR (DO), MOLEZ AM, Ribeiro FV (DO), Tenenbaum HC (PI), Casati MZ (PN), Corrêa MG (DO), Pimentel SP (DO). Resveratrol and insulin association reduced alveolar bone loss and produced an antioxidant effect in diabetic rats. J Periodontol. 2020 Aug 21. Epub ahead of print. PMID: 32827164.
UNIVERSITY OF BERN/ UNIVERSITY OF IOWA COLLEGE OF DENTISTRY
MATUMOTO EK, Corrêa MG (DO), Couso-Queiruga E (PI), Monteiro MF (DO), Graham Z (PI), BRAZ SHG, Ribeiro FV (DO), Pimentel SP (DO), Cirano FR (DO), Casati MZ (DO). Influence of partially exposed nonabsorbable membrane for alveolar ridge preservation: A randomized controlled trial. Clin Implant Dent Relat Res. 2023 Jun;25(3):447-457. doi: 10.1111/cid.13202. Epub 2023 Mar 22. PMID: 36946359.
UNIVERSITÉ de HAUTE-ALSACE
Lima AF (DO), Pizzanelli GG (PI), Stolf CS (PI), Salomon JP (PI), Lalevée J (PI), Andia DC (DO). Novel co-initiators of polymerization: Cytotoxicity profile and modulation of inflammatory mediators in human dental pulp stem cells. Dent Mater. 2024;40(10):1692-6.
5 - Visiting foreign professors or researchers received by the PPG in the four-year period
Prof. Rosiemarie Seelaus: University of Illinois-Chicago: gave a refresher course to PPGO students at UNIP for two weeks right after the Congress of the Latin American Rehabilitation Society, where she presented new methodologies for the production of facial prostheses in 2022.
Prof. Ulf Nannmark: University of Gothenburg/Sweden: In 2022, during the pandemic, Prof. Ulf Nannmark and postgraduate student Anna Larsson participated in virtual (online) activities at UNIP, when they taught theoretical modules focused on the area of extraoral implantology and participated in clinical research.
Professors and international researchers visited the Program's Research Laboratory in 2023, which took place at the same time as the 59th Annual Meeting of the Brazilian Dental Materials Group at UNIP, organized by Prof. Dr. Adriano Lima. During the event, Professors Willian Palin (University of Manchester, Birmingham), Benjamin Gebhardt (Ivoclar, Liechtenstein), Antonio Delgado (Centro de Investigação Interdisciplinar Egas Moniz, Portugal), James Tsoi (The University of Hong Kong, China) and Nick Sillikas (University of Manchester, England) visited the Laboratory, where they discussed research methodologies, providing a rich exchange of knowledge with the Programme's students, who were directly involved in the organization and activities of the event.
6 - Foreign professors/researchers who participated as members of thesis defense committees in the Program during the four-year period
- Rodrigo Ernesto Salazar Gamarra - Uwiener
Francisco Perinni Netto (Master's Degree) - Advisor Prof. Luciano Lauria Dib - Poliana Mendes Duarte - University of Florida
Edson Ken Matumoto (PhD) - Supervisor Prof. Mônica Grazieli Corrêa - Flavia Pires Rodrigues - University of Leeds
Jussara dos Santos Jorge Giorgi (PhD) - Supervisor Prof. Cintia Helena Coury Saraceni - Augusto César Ferreira de Moraes - UTHealth Houston
Ingrid Franco Delgado (PhD) - Supervisor Prof. Cristina Lucia Feijó Ortolani - Franciele Floriani - University of Iowa
Renata Moreira Cançado (Master's) - Supervisor Prof. Alfredo Mikail Melo Mesquita
7 - Foreign students received by the Program on technical visits, short-term missions, sandwich doctorates during the four-year period
SANDWICH DOCTORATE
During the four-year period, three students took part in the Doctorate-Sandwich Program Abroad (PDSE). They are:
- Student Marina Struncová Fernandes, supervised by Prof. Maristela Dutra Correia - University of British Columbia - Canada, under the supervision of Prof. Dr. Adriana Pigozzo Manso, from February to July 2022.
- Student Eduardo Colella, under the supervision of Prof. Suzana Peres Pimentel - University of Florida, Gainesville, USA, in the Department of Periodontics, under the supervision of Prof. Dr. Kesavalu Lakshmyya, from September 2023 to April 2024.
- Student Danielli Mayumi Sato Narimatsu, supervised by Prof. Cintia Saraceni - University of Leeds - UK, in the Biomaterials department, under the supervision of Prof. Dr. Flavia Pires Rodrigues, from October 2024 to March 2025.
8 - Permanent professors and students/graduates of the Program who carried out internships/training, technical visits, research meetings and scientific and technological cooperation in a foreign institution in the four-year period
Prof. Adriano Lima: participated as a Visiting Researcher at the Institute of Materials Science (IS2M), at the Université de Haute-Alsace, Mulhouse-France, between December 2024 and February 2025.
Prof. Matheus Kury Rodrigues: made a technical visit to the University of Bologna-Italy, in the Dental Materials laboratory coordinated by Prof. Dr. Lorenzo Breschi, to learn about the research processes in Restorative Dentistry and Postgraduate Teaching and Research.
Prof. Flávia Pires Rodrigues: JAN-FEB 2023: Made a technical visit to the Poznan Institute of Technology - Lukasiewicz, Poland, for a research internship and presentation of the PPGO as a potential partner in the development of titanium alloys for biological applications. There was an offer of a partnership with the PPGO-UNIP, which is still under evaluation. APR 2023: Visited the Universidad Nacional de Córdoba, Argentina, between April 24 and 28, with students Lucas Dorna de Paula (Master's), Luciana Fernandes Oliveira and Jussara Jorge Giorgi (Doctorate). Coordinated by Prof. Dr. Santiago Daniel Palma, the current Secretary of Innovation and Technological Partnerships of the Argentine government, the mission promoted meetings between research groups, presentations of postgraduate programs and projects, as well as experiments that were carried out in the research laboratory under the supervision of doctoral student Sofía Gisella Brignone, with great rigor and excellence in the preparation of microparticles that will be used in the research of the UNIP group. They also visited the Faculty of Dentistry, the Faculty Museum, the Hemoderivatives Laboratory and the INBIOMED company, where they discussed the development and improvement of materials. The partnership has the potential to be consolidated once an agreement is signed between the groups, with a new mission planned for August. JUN 2023: Returned to the Poznan Institute of Technology - Lukasiewicz, Poland, for three weeks, together with Lucas Dorna de Paula. They developed three formulations of titanium alloys for medical applications. One of the alloys will be presented at an international event in the USA, and another will be part of Camila Rossi's PhD research. The projects involve a consortium with the University of Johannesburg, the University of Limpopo and the University of Babes-Bolyai. JUN 2023: Visited the University of Siegen, Germany, with Lucas Dorna de Paula and Luciana Fernandes de Oliveira. They took part in a joint symposium, experiments to characterize dental materials and tests of the magnetic and bio-reactive properties of particles developed for regenerative periodontal therapy.
9 - Permanent professors and students/graduates of the Program who have acted as lecturers or speakers at international scientific events relevant to the area
Adriano Lima: Speaker at the Symposium held at the “Annual Session of the International Association for Dental Research (IADR) 2024”, in New Orleans, entitled “Interface Between Oral Biology and Next-Generation Biomaterials”, with the lecture entitled “Cell Analysis for Determination of the Cytotoxicity of Dental Materials”.
Speaker at the “Academy of Dental Materials (ADM)”, held in Turin, Italy, from October 2 to 5, 2024, on the topic: “Cytotoxicity/cytokine release from pulp cells induced by new initiators”.
Alfredo Mikail Mesquita: Speaker at the “Latin American Osseointegration Congress - IN2024 - São Paulo”. Titles: “Guided Surgery - Current Status”; “How digital flow can help in everyday cases”.
Speaker at the “40th International Dental Congress of São Paulo - CIOSP”, at the Implacil De Bortoli stand Digital Flow in Prosthesis on Implants, in January 2023. Titles: “Aesthetic Rehabilitation with Digital Flow Veneers”; “Selection of prosthetic abutments: Morse cone and aesthetic region”.
Speaker at the “Latin American Osseointegration Congress - IN202 - São Paulo”. Title: “Digital Resources as a Tool in Implant Dentistry”.
Denise Carleto Andia: Speaker at the 102nd International Academy of Dental, Oral and Craniofacial Research Congress (IADR), New Orleans, USA, March 13-16, 2020, on the topic “The plasticity of molecular mechanisms on the biological effects of a biomaterial” at the “Interface Between Oral Biology and BioMaterials” Symposium. The results of the latest FAPESP grants and articles published by Prof. Denise were presented, which are related to the epigenetic regulation (plasticity) of periodontal ligament cells, in the face of various stimuli (Young Researcher Grant 2013/09650-8 - Assis et al. PLOSONE 2018; Assis et al. DNA and Cell Biology 2021; Regular Bilateral Cooperation Grant FAPESP and University of Birmingham, UK 2017/07944-5 - Assis et al. Developmental Biology 2021; Ferreira et al. Journal of Periodontology 2022; Adolpho et al. Regenerative Medicine 2022; Assis et al. Cells 2022; Ferreira et al. Oral Diseases 2023; Ferreira et al. Genes 2023).
Speaker during the “International Congress of Science, Technology and Development”, October 20-22, 2022, in online format. Title: “Mesenchymal cells of the periodontal ligament: from the bench to the clinic. An epigenetic vision”.
Flávia Pires Rodrigues: Speaker during the “4th Mansour International Dental Congress - Mansoura - Egypt”, from October 19 to 21, 2022. Title: “Effective scientific writing”.
Luciano L. Dib: Speaker together with graduate Rodrigo Salazar Gamarra (Peru) at the “Professional Improvement Course of the Latin American Society of Oral and Maxillofacial Rehabilitation” - training courses for the rehabilitation of patients with deformities due to trauma and tumors, in different centers in Latin America, such as Cuba, Chile, Colombia, Peru, Argentina, Uruguay.
Speaker at the “IN 24 Latin American Osseointegration Congress”, on September 26, 2024, in São Paulo - SP. Title: “Osteonecrosis of the jaws”.
Speaker at the “41st International Dental Congress of São Paulo 2024”. Title: “Facial rehabilitation, science, technology and art for recovering quality of life”.