Ementa:
Testes diagnósticos baseados na utilização da Biologia Molecular. Emprego e objetivos das diferentes técnicas de Biologia Molecular utilizadas em Odontologia. Aplicação científica de técnicas como PCR Real Time, DNA-DNA Checkerboard e Clonagem de DNA. Perspectivas do uso de Biologia Molecular para o desenvolvimento da prática odontológica.
Bibliografia:
ALBERTS B et al. Biologia Molecular da Célula. Tradução Ana Letícia de Souza Vanz et al. 6ª ed. Porto Alegre: Artmed; 2017.
ARIAS-BUJANDA N, REGUEIRA-IGLESIAS A, BALSA-CASTRO C, NIBALI L, DONOS N, TOMÁS I. Accuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: A systematic review and meta-analysis. J Clin Periodontol. 2019 Dec;46(12):1166-1182.
BAIMA G, CORANA M, IADEROSA G, ROMANO F, CITTERIO F, MEONI G, TENORI L, AIMETTI M. Metabolomics of gingival crevicular fluid to identify biomarkers for periodontitis: A systematic review with meta-analysis. J Periodontal Res. 2021 Aug;56(4):633-645.
CHAVES DE SOUZA JA, FRASNELLI SC, CURYLOFO-ZOTTI FA, ÁVILA-CAMPOS MJ, SPOLIDÓRIO LC, ZAMBONI DS, GRAVES DT, ROSSA C JR. NOD1 in the modulation of host-microbe interactions and inflammatory bone resorption in the periodontal disease model. Immunology. 2016;149(4):374-385.
DABDOUB SM, TSIGARIDA AA, KUMAR PS. Patient-specific Analysis of Periodontal and Peri-implant Microbiomes. J Dent Res. 2013 Dec;92(12 Suppl):168S-75S. doi: 10.1177/0022034513504950.
FAULKNER E, MENSAH A, RODGERS AM, MCMULLAN LR, COURTENAY AJ. The Role of Epigenetic and Biological Biomarkers in the Diagnosis of Periodontal Disease: A Systematic Review Approach. Diagnostics (Basel). 2022 Apr 7;12(4):919.
GRDOVIĆ N, RAJIĆ J, PETROVIĆ SM, DINIĆ S, USKOKOVIĆ A, MIHAILOVIĆ M, JOVANOVIĆ JA, TOLIĆ A, PUCAR A, MILAŠIN J, VIDAKOVIĆ M. Association of CXCL12 gene promoter methylation with periodontitis in patients with diabetes mellitus type 2. Arch Oral Biol. 2016;72:124-133.
GUPTA S, CHHINA S, ARORA SA. A systematic review of biomarkers of gingival crevicular fluid: Their predictive role in diagnosis of periodontal disease status. J Oral Biol Craniofac Res. 2018 May-Aug;8(2):98-104
JOSHI C, BAPAT R, ANDERSON W, DAWSON D, CHERUKARA G, HIJAZI K. Serum antibody response against periodontal bacteria and coronary heart disease: Systematic review and meta-analysis. J Clin Periodontol. 2021 Dec;48(12):1570-1586.
KC S, WANG XZ, GALLAGHER JE. Diagnostic sensitivity and specificity of host-derived salivary biomarkers in periodontal disease amongst adults: Systematic review. J Clin Periodontol. 2020 Mar;47(3):289-308.
KOIDOU VP, CAVALLI N, HAGI-PAVLI E, NIBALI L, DONOS N. Expression of inflammatory biomarkers and growth factors in gingival crevicular fluid at different healing intervals following non-surgical periodontal treatment: A systematic review. J Periodontal Res. 2020 Dec;55(6):801-809.
VIOLANT D, GALOFRÉ M, NART J, TELES RP. In vitro evaluation of a multispecies oral biofilm on different implant surfaces. Biomed Mater. 2014 Jun;9(3):035007.
ZAHA A, FERREIRA HB, PASSAGLIA L M. P. Biologia Molecular Básica. 5ª ed. Porto Alegre: Artmed; 2014.
Periódicos:
International Journal of Periodontics and Restorative Dentistry
Journal of Clinical Periodontology
Journal of Periodontal Research
Journal of Periodontology